血清FOXO3和TXNIP对老年PCI术后患者发生主要心血管不良事件的预测价值  

Predictive value of serum FOXO3 and TXNIP for major adverse cardiovascular event in elderly patients after PCI

作　　者：谢立新 李桂娇 XIE Lixin;LI Guijiao(Second District,Department of Cardiology,The Third People’s Hospital of Nanning,Nanning 530003,China)

机构地区：[1]南宁市第三人民医院心内科二区,南宁530003

出　　处：《中国医科大学学报》2025年第4期301-305,共5页Journal of China Medical University

基　　金：广西壮族自治区卫生健康委员会自筹经费科研项目(Z-A20221200)。

摘　　要：目的探讨血清叉头框蛋白O3(FOXO3)和硫氧还蛋白相互作用蛋白(TXNIP)对老年冠状动脉粥样硬化性心脏病(CHD)经皮冠状动脉介入治疗(PCI)患者术后发生主要心血管不良事件(MACE)的预测价值。方法选取2021年6月至2023年5月我院收治的120例老年CHD患者为研究对象,患者均行PCI。随访12个月后(失访6例),根据患者是否发生MACE(复发心绞痛、急性心肌梗死、严重心律失常)分为MACE组(n=40)和非MACE组(n=74)。采用酶联免疫吸附试验(ELISA)检测血清中FOXO3和TXNIP水平;采用Pearson相关分析评估CHD患者血清FOXO3和TXNIP水平的相关性;受试者操作特征(ROC)曲线分析血清FOXO3和TXNIP对CHD患者PCI术后发生MACE的预测价值。logistic回归分析影响CHD患者PCI术后MACE发生的因素。结果与非MACE组相比,MACE组患者血清中FOXO3水平显著降低,TXNIP水平显著升高(P<0.05)。Pearson相关分析显示,CHD患者血清FOXO3和TXNIP水平呈负相关(r=-0.586,P<0.001)。logistic回归分析结果显示,FOXO3和TXNIP是CHD患者PCI术后发生MACE的影响因素(P<0.05)。血清FOXO3和TXNIP联合预测CHD患者PCI术后发生MACE的曲线下面积(AUC)高于FOXO3和TXNIP单独预测(Z=7.583,P<0.001;Z=8.640,P<0.001)。结论PCI术后发生MACE的CHD患者血清中FOXO3呈低表达,TXNIP呈高表达,FOXO3和TXNIP对老年CHD患者PCI术后发生MACE有临床预测价值。Objective To investigate the predictive value of serum forkhead box protein O3(FOXO3)and thioredoxin interacting protein(TXNIP)for major adverse cardiovascular event(MACE)in elderly patients with coronary heart disease(CHD)following percutaneous coronary intervention(PCI).Methods In total,120 elderly patients with CHD who underwent successful PCI at our hospital between June 2021 and May 2023 were enrolled.After 12 months of follow-up(6 patients lost to follow-up),the patients were divided into the MACE group(n=40)and non-MACE group(n=74)based on whether they experienced MACE,such as recurrent angina pectoris,acute myocardial infarction,and severe arrhythmia.Enzyme-linked immunosorbent assay was used to detect FOXO3 and TXNIP levels in serum.The Pearson analysis was used to analyze the correlation between serum FOXO3 and TXNIP levels in patients with CHD.A receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum FOXO3 and TXNIP levels for MACE in patients with CHD after PCI.Logistic regression was used to analyze the factors affecting the occurrence of MACE in patients with CHD after PCI.Results The serum FOXO3 level in the MACE group was significantly lower than that in the non-MACE group,while TXNIP levels were significantly higher(P<0.05).Pearson analysis revealed that serum FOXO3 and TXNIP levels in patients with CHD were negatively correlated(r=-0.586,P<0.001).Logistic regression analysis revealed that FOXO3 and TXNIP were factors influencing MACE in patients with CHD after PCI(P<0.05).The combined prediction of serum FOXO3 and TXNIP for MACE in patients with CHD after PCI had higher area under the curve than using FOXO3 and TXNIP alone(Z=7.583,P<0.001;Z=8.640,P<0.001).Conclusion The elderly CHD patients with MACE after PCI showed low FOXO3 expression and high TXNIP expression,which have a clinical predictive value for MACE occurrence in patients with CHD after PCI.

关 键 词：叉头框蛋白O3 硫氧还蛋白相互作用蛋白 冠状动脉粥样硬化性心脏病 经皮冠状动脉介入治疗 

分 类 号：R540.4[医药卫生—心血管疾病]