血清vWF、MCP-1、GDF-15联合检测对凶险性前置胎盘患者产后出血的预测价值  

Predictive value of combined detection of serum vWF,MCP-1,and GDF-15 for postpartum hemorrhage in patients with pernicious placenta previa

作　　者：刘慧强[1] 魏琰平 孟斐 张雯 刘喜翠 丁妮娜 LIU Huiqiang;WEI Yanping;MENG Fei;ZHANG Wen;LIU Xicui;DING Nina(Department of Obstetrics and Gynecology,Second Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第二医院妇产科,太原030000

出　　处：《中国医科大学学报》2025年第4期346-350,358,共6页Journal of China Medical University

基　　金：山西省基础研究计划(202203021221277)。

摘　　要：目的探讨血清血管性血友病因子(vWF)、单核细胞趋化蛋白-1(MCP-1)、生长分化因子-15(GDF-15)联合检测对凶险性前置胎盘(PPP)患者产后出血的预测价值。方法选取我院2021年1月至2024年1月收治的PPP患者112例(研究组),将其分为产后出血组和非产后出血组,并选取同期胎盘位置正常孕妇112例(对照组),用ELISA检测血清vWF、MCP-1、GDF-15水平。结果研究组血清vWF、MCP-1、GDF-15水平显著高于对照组(P<0.05)。产后出血组PPP患者血清vWF、MCP-1、GDF-15水平显著高于非产后出血组PPP患者(P<0.05)。logistic回归分析发现,vWF、MCP-1、GDF-15为PPP产后出血的影响因素(P<0.05)。血清vWF、MCP-1、GDF-15三者联合检测预测PPP产后出血优于单独检测(P<0.05)。结论血清vWF、MCP-1、GDF-15联合检测对PPP产后出血有一定的预测价值。Objective To investigate the predictive value of the combined detection of serum von Willebrand factor(vWF),monocyte chemotactic protein-1(MCP-1),and growth differentiation factor-15(GDF-15)for postpartum hemorrhage in patients with pernicious placenta previa(PPP).Methods One hundred and twelve patients with PPP admitted to our hospital between January 2021 and January 2024 were selected as the study group.They were further divided into a postpartum hemorrhage group and a non-postpartum hemorrhage group and 112 pregnant women with normal placental position during the same period were selected as the control group.ELISA was used to detect serum vWF,MCP-1,and GDF-15 levels.Results Serum vWF,MCP-1,and GDF-15 levels were significantly higher in the study group than in the control group(P<0.05).Serum vWF,MCP-1,and GDF-15 levels were significantly higher in the postpartum hemorrhage group than in the non-postpartum hemorrhage group(P<0.05).Logistic regression analysis identified vWF,MCP-1,and GDF-15 levels as factors influencing postpartum hemorrhage for women with PPP(P<0.05).The combination of serum vWF,MCP-1,and GDF-15 predicted postpartum hemorrhage in women with PPP better than either factor alone(P<0.05).Conclusion Combined detection of serum vWF,MCP-1,and GDF-15 levels has predictive value for postpartum hemorrhage in women with PPP.

关 键 词：血管性血友病因子 单核细胞趋化蛋白-1 生长分化因子-15 凶险性前置胎盘 产后出血 预测 

分 类 号：R714.56[医药卫生—妇产科学]