艾司氯胺酮在围手术期镇痛的应用进展  

Progress of the use of esketamine in perioperative analgesia

作　　者：张小媚 温君琳 廖小卒[2] 黄锡强[2] 李斌飞 Zhang Xiaomei;Wen Junlin;Liao Xiaozu;Huang Xiqiang;Li Binfei(Guangdong Medical University,Zhanjiang 524023,China;Department of Anesthesiology,Zhongshan City People’s Hospital,Zhongshan 528404,China)

机构地区：[1]广东医科大学,湛江524023 [2]广东省中山市人民医院麻醉科,528404

出　　处：《中华普通外科学文献(电子版)》2025年第2期130-134,共5页Chinese Archives of General Surgery(Electronic Edition)

基　　金：中山市社会公益与基础研究项目(2023B1017)。

摘　　要：艾司氯胺酮是一种具有显著镇痛效应的N-甲基-D-天冬氨酸受体的非竞争性抑制药,在麻醉诱导与维持、抗抑郁治疗等方面呈现出显著优势。与传统的镇痛药物相比,艾司氯胺酮可提供多维的镇痛效果,效力更高且不良反应少,在围手术期镇痛的应用越来越受到关注。本文对艾司氯胺酮镇痛的机制及其在围手术期镇痛中的应用进行综述,以期为其在围手术期镇痛应用提供参考。Esketamine is a non-competitive N-methyl-D-aspartate receptor antagonist with significant analgesic effects,and has shown important advantages in the antidepressant treatment,anesthesia induction and maintenance.Compared with traditional analgesic drugs,esketamine has a unique mechanism of action,higher potency and relatively fewer side effects,and its application in perioperative analgesia has attracted more and more attention.This article reviews the analgesic mechanism of esketamine and its application in perioperative analgesia,in order to provide reference for its application in perioperative analgesia.

关 键 词：艾司氯胺酮 围手术期 镇痛 

分 类 号：R614[医药卫生—麻醉学]