系统性红斑狼疮小鼠模型对比与应用研究进展  

Research progress in the comparison and application of mouse models with systemic lupus erythematosus

作　　者：先家辉 邢艳 XIAN Jiahui;XING Yan(Department of Clinical Biochemistry,School of Medical Lab Science,North Sichuan Medical College,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Clinical laboratory,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院1检验医学院临床生物化学教研室,四川南充637000 [2]川北医学院附属医院检验科,四川南充637000

出　　处：《细胞与分子免疫学杂志》2025年第3期262-270,共9页Chinese Journal of Cellular and Molecular Immunology

基　　金：南充市科技局市校合作项目(20SXQT0022)。

摘　　要：系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病,临床症状复杂多样,广泛累及包括肾脏、心血管、神经在内的多个系统和器官,免疫系统错误地攻击自身组织为其主要特征,但具体发病机制目前尚不明确。本文对自发性和人工诱导性SLE小鼠模型的造模机制及主要病理表现进行评述和比较,可为SLE发病机制、临床诊断和治疗等研究提供选择适当小鼠模型的依据。Systemic lupus erythematosus(SLE)is a complex autoimmune disease with diverse clinical symptoms,which involves multiple systems and organs such as the kidney,cardiovascular system,and nervous system.The main characteristic of SLE is the mistaken attacks on self-tissues by the immune system,but the specific pathogenesis is still unclear.This paper reviews and compares the modeling mechanisms and main pathological manifestations of spontaneous and experimental mouse models of SLE,which can provide evidences for selecting appropriate mouse models in studies on the pathogenesis,clinical diagnosis and treatment of SLE.

关 键 词：系统性红斑狼疮(SLE) 小鼠模型 自身免疫性疾病 综述 

分 类 号：R392[医药卫生—免疫学] R593.241[医药卫生—基础医学] G353.11[文化科学—情报学]