间充质干细胞来源外泌体在肺部疾病治疗中的研究进展  

Advances in the study of exosomes derived from mesenchymal stem cells in the treatment of pulmonary diseases

作　　者：马涛 乐林芝 代禹美 杜文雅 吴利先 MA Tao;YUE Linzhi;DAI Yumei;DU Wenya;WU Lixian(Department of Microbiology and Immunology,School of Basic Medicine,Dali University,Dali 671000,China)

机构地区：[1]大理大学基础医学院微生物与免疫学教研室,云南大理671000

出　　处：《细胞与分子免疫学杂志》2025年第3期278-282,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：云南省地方本科高校基础研究重点项目(202101BA070001-038)。

摘　　要：肺部疾病作为一类呼吸系统常见疾病,已然成为全球公共卫生的主要问题。由于环境的污染以及职业因素的影响,肺部疾病的发病率正在逐年上升,严重影响了人类的健康和生活质量。间充质干细胞(MSC)具有参与免疫调节、抗菌、抗凋亡的作用,来源于MSC的外泌体携带蛋白质、脂质、核酸等物质在肺部疾病的治疗中展现出良好的效果,受到了医学界的广泛关注。本文综述了不同来源的MSC外泌体在肺部疾病中的作用,为临床诊治应用提供依据。Pulmonary diseases,as a prevalent category of respiratory system disorders,have become a significant global public health concern.The increasing incidence of these diseases,caused by environmental pollution and occupational hazards,poses a substantial threat to human health and the overall quality of life.Mesenchymal stem cells(MSCs)are known for their remarkable immunomodulatory,anti-bacterial,and anti-apoptotic capabilities.Exosomes derived from MSCs,carrying a diverse array of proteins,lipids,nucleic acids,and other bio-active molecules,have demonstrated considerable therapeutic potential in treating pulmonary diseases,and have come to the forefront of medical research.This review summarized the therapeutic role of exosomes derived from various sources of mesenchymal stem cells in the context of pulmonary diseases,aiming to provide a robust foundation for their clinical application in diagnosis and treatment.

关 键 词：间充质干细胞(MSC) 外泌体 肺部疾病 治疗 综述 

分 类 号：R392[医药卫生—免疫学] R563[医药卫生—基础医学] G353.11[文化科学—情报学]