基于文献回顾探析复发性口腔溃疡的证素分布特点及组合规律  

Analysis of the Distribution of Characteristics and Combination Rules of Syndrome Elements in Recurrent Oral Ulcers Based on Literature Review

作　　者：傅天啸 卢雯雯[1] 胡凤林 吴国琳[1] FU Tianxiao;LU Wenwen;HU Fenglin(The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou(310003),China)

机构地区：[1]浙江大学医学院附属第一医院,杭州310003

出　　处：《浙江中医药大学学报》2025年第3期326-332,共7页Journal of Zhejiang Chinese Medical University

基　　金：浙江省卫健委2023年度浙江省中医药创新团队资助项目(浙卫发〔2023〕31号)。

摘　　要：[目的]通过提取近年复发性口腔溃疡文献中的证素,总结证素分布特点及组合规律,分析病因病机,为临床中医诊治提供理论依据。[方法]对中国知网、万方数据库中近4年与复发性口腔溃疡相关的临床文献进行检索,提取证候、证素等关键信息,建立信息数据库,进行频次分析。[结果]纳入文献161篇,提取复发性口腔溃疡规范的中医证候26种,心脾郁热证最常见,其次为阴虚火旺证及脾虚湿热证,痰瘀互结证最少。提取脾、心、胃、肝、肾、胆、肺、大肠共8个病位证素,最常见的病位证素为脾,其次为心,大肠频次最少。提取热、血虚、毒等14个病性证素,最常见的为热,其次为阴虚,燥频次最少。证素组合形式共有10种,其中脾+热、心+脾+热、心+火的频次最多,肝+血虚频次最少。[结论]复发性口腔溃疡证型以心脾郁热为主,发病与脾最为密切,病理因素为热。临床治疗复发性口腔溃疡多从脾、心、胃三脏入手,以降火、清热、祛湿三法最为重要。[ObjectiveObjective]To summarize the distribution characteristics and mutual combination rules of syndrome elements through the extraction of syndrome elements from recent literature on recurrent oral ulcers,analyze the etiology and pathogenesis and provide theoretical basis for clinical diagnosis and treatment in traditional Chinese medicine.[MethodsMethods]The clinical literature related to recurrent oral ulcers in the past four years in the China National Knowledge Infrastructure and WanFang databases was searched,key information such as syndromes and syndrome elements was extracted,an information database was established,and frequency analysis was conducted.[ResultsResults]One hundred and sixty-one literatures were included,and 26 standard Chinese medicine syndromes for recurrent oral ulcers were extracted.Heart-spleen heat accumulation syndrome was the most common,followed by Yin deficiency and fire hyperactivity syndrome,dampness-heat due to spleen deficiency syndrome,phlegm and blood stasis were the least common.A total of 8 disease location syndrome elements were extracted from the spleen,heart,stomach,liver,kidney,gallbladder,lung and large intestine.The most common disease location syndrome was the spleen,followed by the heart,and the large intestine was the least frequent.Fourteen disease syndrome elements including heat,blood deficiency,and poison were extracted.The most common was heat,followed by Yin deficiency,and dryness was the least frequent.There were 10 combinations of syndrome elements,among which spleen+heat,heart+spleen+heat,heart+fire were the most frequent,and liver+blood deficiency was the least frequent.[ConclusionConclusion]The main type of recurrent oral ulcers is characterized by heart-spleen heat accumulation,which is most closely related to the spleen,the pathological factor is heat.Clinical treatment of recurrent oral ulcers often starts with the three organs of the spleen,heart and stomach,with the three most important methods of reducing fire,clearing heat and eliminating dampne

关 键 词：复发性口腔溃疡 心脾郁热 证素 病位 病性 证候 中医 文献回顾 

分 类 号：R276[医药卫生—中医五官科学]