白桦脂醇纳米乳处方筛选及制备工艺优化研究  

Formulation screening and preparation process optimization of betulin nanoemulsion

作　　者：王德旺 蒙天琛 李鑫[1] WANG Dewang;MENG Tianchen;LI Xin(College of Pharmacy,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076

出　　处：《天津中医药》2025年第4期486-495,共10页Tianjin Journal of Traditional Chinese Medicine

基　　金：黑龙江省重点研发计划指导类项目(GZ20210092)。

摘　　要：[目的]确定白桦脂醇纳米乳的制备工艺处方。[方法]采用伪三元相图法筛选纳米乳处方。采用单因素筛选和效应面法(Box-Behnken)优化制备工艺参数。[结果]白桦脂醇纳米乳的最优处方为:m(肉豆蔻酸异丙酯)∶m(吐温80)∶m(丙三醇)∶m(蒸馏水)=15.38%∶20.51%∶41.03%∶23.08%。最优处方工艺为:搅拌温度53℃,搅拌速度1050 r/min,搅拌时间6.2 min。[结论]确定的处方工艺稳定简便,重复性好,制得的纳米乳载药量较高。[Objective]To determine the process prescription for the preparation of Betulinol nano-emulsion.[Methods]Pseudo-ternary phase diagram method was used to screen the nano-emulsion prescription.The preparation process parameters were optimized using one-factor screening and effect surface method(Box-Behnken).[Results]The optimal prescription of betulinol nano-emulsion was:m(isopropyl myristate)∶m(tween 80)∶m(glycerol)∶m(distilled water)=15.38%∶20.51%∶41.03%∶23.08%.The optimum prescription process was:stirring temperature 53℃,stirring speed 1050 r/min,stirring time 6.2 min.[Conclusion]The determined prescription process was stable and simple,reproducible,and produced nanoemulsions with high drug loading capacity.

关 键 词：白桦脂醇 纳米乳 处方筛选 制备工艺 

分 类 号：R283.6[医药卫生—中药学]