中医药调控HIF-1α信号通路治疗心肌缺血再灌注损伤的研究进展  

Research progress of HIF-1α signaling pathway regulated by traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury

作　　者：刘祎曼 贾慧雨 冯文帅 郭流漓 江丰[1] 任明[2] LIU Yiman;JIA Huiyu;FENG Wenshuai;GUO Liuli;JIANG Feng;REN Ming(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Baokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine,Tianjin 300073,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学附属保康医院,天津300073

出　　处：《天津中医药》2025年第4期519-525,共7页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1707403)。

摘　　要：急性心肌梗死通过溶栓、扩管等药物,以及经皮冠状动脉介入术能够最大限度地减少心肌缺血性损伤,限制梗死面积,但恢复缺血心肌组织的血液灌注将导致心肌缺血再灌注损伤(MIRI)。近年来研究发现,中医药在治疗MIRI方面具有多成分、多途径、多靶点的独特优势。缺氧诱导因子-1α(HIF-1α)在MIRI过程中可以通过调节氧化应激、炎症反应、血管生成、细胞凋亡和自噬等途径促进细胞的存活和恢复,降低心肌损伤程度,在MIRI中发挥重要作用。文章总结了HIF-1α信号通路与MIRI发病机制之间的联系,并概述了中医药在调节HIF-1α信号通路以治疗MIRI方面的研究进展,以期为中医药防治MIRI提供新思路。Acute myocardial infarction can minimize myocardial ischemic damage and limit the infarct size by thrombolysis,drugs that dilate blood vessels,and percutaneous coronary intervention,but restoration of blood perfusion of ischemic myocardial tissue will lead to myocardial ischemia-reperfusion injury(MIRI).In recent years,it has found that traditional Chinese medicine(TCM)has the unique advantages of multi-component,multi-pathway and multi-target in the treatment of MIRI.Hypoxia-inducible factor 1 alpha(HIF-1α)plays an important role in promoting cell survival and recovery and reducing the degree of myocardial damage by regulating oxidative stress,inflammatory response,angiogenesis,apoptosis and autophagy during MIRI.Therefore,this paper summarized the relationship between HIF-1α signaling pathway and the pathogenesis of MIRI,as well as the current research progress of TCM in regulating HIF-1α signaling pathway to treat MIRI,in order to provide new ideas for the prevention and treatment of MIRI with TCM.

关 键 词：HIF-1α信号通路 中医药 心肌缺血再灌注损伤 研究进展 

分 类 号：R542.22[医药卫生—心血管疾病]