新型含铝疫苗佐剂的研究进展  

Research progress of new aluminum-containing vaccine adjuvants

作　　者：任红梅 熊晔蓉[1] 荀校莹 姜雷 涂家生[1] REN Hongmei;XIONG Yerong;XUN Xiaoying;JIANG Lei;TU Jiasheng(Center for R&D and Evaluation of Pharmaceutical Excipients and Generic Drugs,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药学院,药用辅料及仿创药物研发评价中心,南京210009

出　　处：《中国药科大学学报》2025年第2期236-243,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金项目(No.32271456)。

摘　　要：铝佐剂因其诱导高效持久的免疫应答作用和良好的安全性在疫苗领域被广泛应用。随着免疫学的发展,对于佐剂的要求逐渐提高,传统铝佐剂已无法满足某些应用需求。因此,为实现良好的免疫增强效果及诱导特定类型和强度的免疫反应,新型铝佐剂的开发已成为研究热点。本综述介绍了铝佐剂的作用机制及安全性,并重点概述了近年来新型铝佐剂的研究进展,主要包括纳米铝佐剂和复合铝佐剂(铝佐剂与免疫刺激分子或递送载体复合),并对其未来的研究方向进行了展望,以期为铝佐剂的进一步开发和临床应用提供参考。Aluminum adjuvants are widely used in the field of vaccines due to their ability to induce efficient and long-lasting immune responses and good safety profile.With the development of immunology,the requirements for adjuvants have gradually increased,and traditional aluminum adjuvants can no longer meet all the needs of application.The development of novel aluminum adjuvants has become a hot research topic in order to achieve good immunity-enhancing effects and induce specific types and strengths of immune responses.This review briefly introduces the mechanism of action and safety of aluminum adjuvants,with focus on the research progress of novel aluminum adjuvants in recent years,mainly including nano-aluminum adjuvants and composite aluminum adjuvants(aluminum adjuvants compounded with immunity-stimulating molecules or delivery carriers),and a prospect of their future research direction,aiming to provide some reference for the further development and clinical application of aluminum adjuvants.

关 键 词：疫苗 铝佐剂 纳米铝佐剂 复合铝佐剂 免疫反应 

分 类 号：R392[医药卫生—免疫学] R979.5[医药卫生—基础医学]