两样本孟德尔随机化方法探究体重指数与痛风的因果关系  

Two sample Mendelian randomization method to investigate the causal relationship between body mass index and gout

作　　者：肖美娣 张文文 周瑾[1,3] XIAO Mei-di(TCM College of Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China)

机构地区：[1]湖北中医药大学中医学院,湖北武汉430065 [2]湖北中医药大学第一临床学院,湖北武汉430065 [3]深圳市第二人民医院中医科,广东深圳518000

出　　处：《牡丹江医科大学学报》2025年第2期32-35,46,共5页Journal of Mudanjiang Medical University

基　　金：国家自然科学基金项目(30873345)。

摘　　要：目的运用两样本孟德尔随机化方法探究体重指数与痛风之间的因果关系。方法暴露因素BMI的数据来源于欧洲IEU数据库(The IEU GWAS Database),疾病结局痛风的数据来源于芬兰数据库(The FinnGen Biobank),筛选出BMI相关的单核苷酸多态性位点,参数设为P<5×10^(-8),连锁不平衡r^(2)<0.001,kb<10000,孟德尔随机化分析主要运用IVW、ME、WME、SM和WM共5种互补的方法进行分析,以OR以及95%CI为依据评价BMI与痛风的之间因果关系。为确保研究结果的可靠性,还进行了敏感性分析,主要包括异质性检验、水平多效性、逐个剔除检验。结果IVW结果显示OR=1.627(95%CI:1.396~1.896),P=4.38E-10<0.01;MR-Egger结果显示OR=1.596(95%CI:1.063~2.397),P=0.025<0.05;WME结果显示OR=1.443(95%CI:1.218~1.708),P=2.17E-05<0.01;SM结果显示OR=1.194(95%CI:0.650~2.190),P=0.568>0.05;WM结果显示OR=1.383(95%CI:0.995~1.923),P=0.054>0.05。结论欧洲人群中随着体重指数的升高,罹患痛风的概率也会随之增加。Objective The two-sample Mendelian randomization method was used to explore the causal relationship between body mass index and Gout.Methods The data of exposure factor BMI were derived from The IEU GWAS Database,and the data of disease outcome Gout were derived from The FinnGen Biobank.SNPs associated with BMI were selected and the parameter was set as P<5×10^(-8),chain imbalance r^(2)<0.001,kb<10000,Mendelian randomization analysis mainly uses IVW,ME,WME,SM and WM,the causal relationship between BMI and gout was evaluated according to OR and 95%CI.In order to ensure the reliability of the research results,sensitivity analysis was also carried out,which mainly included heterogeneity test,horizontal pleiotropy test and one-by-one elimination test.Results IVW results showed that OR=1.627(95%CI:1.396~1.896),P=4.38E-10<0.01;The MR-Egger result showed that OR=1.596(95%CI:1.063~2.397),P=0.025<0.05;WME results showed that OR=1.443(95%CI:1.218~1.708),P=2.17E-05<0.01;SM results showed that OR=1.194(95%CI:0.650~2.190),P=0.568>0.05.WM results showed that OR=1.383(95%CI:0.995~1.923),P=0.054>0.05.Conclusion The risk of gout increases with the increase of body mass index in the European population.

关 键 词：痛风 体重指数 孟德尔随机化 因果关系 双样本 

分 类 号：R259[医药卫生—中西医结合] R589.7[医药卫生—中医内科学]