硫酸水相单端基保护法合成N-(2-羟丙基)哌嗪  

Synthesis of N-(2-hydroxypropyl)piperazine by mono-end-protection in aqueous phase of sulfuric acid

作　　者：蒋倩文 徐卫 贾邵竣 崔鹏 徐辉 王光应 JIANG Qianwen;XU Wei;JIA Shaojun;CUI Peng;XU Hui;WANG Guangying(School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei 230009,China;Anhui Yuanchen Environmental Protection Technology Co.,Ltd.,Hefei 230012,China)

机构地区：[1]合肥工业大学化学与化工学院,安徽合肥230009 [2]安徽元琛环保科技股份有限公司,安徽合肥230012

出　　处：《合肥工业大学学报(自然科学版)》2025年第4期518-523,共6页Journal of Hefei University of Technology:Natural Science

基　　金：安徽省科技重大专项资助项目(201903a07020004)。

摘　　要：文章以哌嗪(PZ)和环氧丙烷(PO)为原料,硫酸(H_(2)SO_(4))为单端基保护剂,在水相中PZ首先与H_(2)SO_(4)发生单质子化反应生成PZ(H)^(+),再与亲电试剂PO发生反应,通过Ba(OH)_(2)脱保护后,过滤分离BaSO_(4)沉淀制得N-(2羟丙基)哌嗪(HPPZ)。该研究考察了PZ质子化程度、PZ初始质量和PO用量对HPPZ收率的影响,结果表明,当50.0 mL水中PZ初始质量为10.0 g,PZ、H_(2)SO_(4)、PO三者的摩尔比为2∶1∶2时,初始pH值为8.23,PZ单边反应生成HPPZ的收率可达84%,显著优于PZ与PO直接水相法合成HPPZ的收率。In this paper,piperazine(PZ)and propylene oxide(PO)were adopted as reactants,and sulfuric acid(H_(2)SO_(4))was applied to protect the mono-ended group.PZ was first reacted with H_(2)SO_(4)in aqueous phase to give PZ(H)^(+),and further reacted with electrophilic reagent PO.The deprotection was carried out by adding Ba(OH)_(2),and N-(2-hydroxypropyl)piperazine(HPPZ)was prepared after the separation of BaSO_(4).The influences of the protonation of PZ,the initial concentration of PZ,and the addition amount of PO on the HPPZ yield were also investigated.The results show that the HPPZ yield can reach 84%by unilateral reaction of PZ when the initial concentration of PZ is 10.0 g in 50.0 mL water,the molar ratio of PZ,H_(2)SO_(4),and PO is 2∶1∶2,and the initial pH value of the solution is 8.23,which is significantly superior than that by the direct aqueous phase reaction of PZ with PO.

关 键 词：哌嗪(PZ) 环氧丙烷(PO) N-(2-羟丙基)哌嗪(HPPZ) 单质子化 单端基保护 

分 类 号：O621.3[理学—有机化学]