高龄妊娠期糖尿病患者血清SOCS3、FABP4、CysC水平与妊娠结局的关系及临床意义  

The relationship and clinical significance of serum SOCS3,FABP4,CysC levels with pregnancy outcome in elderly pregnant women with diabetes

作　　者：李雪艳 许军秀[1] 王亚奇 LI Xue-yan;XU Jun-xiu;WANG Ya-qi(Department of Laboratory Medicine,The Fifth Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450000)

机构地区：[1]郑州大学第五附属医院医学检验科,河南郑州450000

出　　处：《医学检验与临床》2025年第3期15-19,共5页Medical Laboratory Science and Clinics

摘　　要：目的:探讨高龄患者血清细胞因子信号转导抑制因子3(SOCS3)、脂肪酸结合蛋白质4(FABP4)、半胱氨酸蛋白酶抑制剂C(CysC)与妊娠结局的关系及临床意义。方法:选取我院2022年1月-2024年1月收治的68例高龄妊娠期糖尿病妇女为研究对象,根据妊娠结局分为妊娠良好组和妊娠不良组。对比不同妊娠结局患者孕30、36周时血清SOCS3、FABP4、CysC水平;分析血清各指标水平与妊娠结局的相关性;ROC分析血清各指标对高龄妊娠期糖尿病患者妊娠不良的预测价值;分析血清各指标不同水平患者发生妊娠不良的危险度。结果:孕30、36周妊娠不良患者血清SOCS3、FABP4、CysC水平高于妊娠良好患者(P<0.05);血清SOCS3、FABP4、CysC水平与妊娠不良呈正相关(P<0.05);孕30、36周血清SOCS3、FABP4、CysC水平联合预测治疗无效的AUC为0.749、0.856;孕30、36周血清SOCS3、FABP4、CysC高水平患者发生妊娠不良的危险度是低水平的3.913、3.637、3.037/4.300、3.900、3.231倍(P<0.05)。结论:高龄妊娠期糖尿病患者体内SOCS3、FABP4、CysC水平与妊娠结局密切相关,临床检测其表达是评估患者妊娠结局的有效手段。Objective:To explore the relationship and clinical significance of serum cytokine signal transduction inhibitor 3(SOCS3),fatty acid binding protein 4(FABP4),cysteine protease inhibitor C(CysC)and pregnancy outcome in elderly pregnant women with diabetes.Methods:Sixty-eight cases ofelderly women with gestational diabetes mllitus admitted to our hospital fromJanuary 2022 to January 2024 were selected as the study subjects,and were divided into the good pregnancy group and the bad pregnancy group according to the pregnancy outcome.The serum SOCS3,FABP4 and CysC levels at 30 and 36 weeks of pregnancy in patients with different pregnancy outcomes were compared;The correlation between the levels of each serum index and pregnancy outcomes were analyzed;ROC analyzed the predictive value of each serum index for poor pregnancy in patients with diabetes mellitus in advanced gestational age;and the risk of poor pregnancy in patients with different levels of each serum index were analyzed.Results:The levels of serum SOCS3,FABP4,and CysC in patients with adverse pregnancy at 30 and 36 weeks of gestation were higher than those in patients with good pregnancy(P<0.05);The levels of serum SOCS3,FABP4,and CysC were positively correlated with adverse pregnancy(P<0.05);The AUC of serum SOCS3,FABP4,and CysC levels combined to predict ineffective treatment at 30 and 36 weeks of gestation was 0.749 and 0.856;The risk of adverse pregnancy in patients with high levels of serum SOCS3,FABP4,and CysC at 30 and 36 weeks of gestation was 3.913,3.637,3.037/4.300,3.900,and 3.231 times higher than that in patients with low levels(P<0.05).Conclusion:The levels of SOCS3,FABP4 and CysC in the elderly patients with gestational diabetes are closely related to the pregnancy outcome.Clinical detection of their expression is an effective means to evaluate the pregnancy outcome of patients with gestational diabetes.

关 键 词：SOCS3 FABP4 CYSC 高龄妊娠糖尿病 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]