Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study  

作　　者：Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang 

机构地区：[1]National Clinical Research Center for Metabolic Diseases,Metabolic Syndrome Research Center,Key Laboratory of Diabetes Immunology,Ministry of Education,and Department of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University,CSU-Sinocare Research Center for Nutrition and Metabolic Health,Xiangya School of Public Health,Central South University,Furong Laboratory,Changsha,410011,China [2]Division of Cancer Epidemiology and Genetics,National Cancer Institute,NIH,Department of Health and Human Services,Bethesda,MD,20892,USA [3]School of Computer Science and Engineering,Central South University,Changsha,410083,China [4]Institute of Environmental Medicine,Karolinska Institute,Stockholm,17177,Sweden [5]National Clinical Research Center for Metabolic Diseases,Key Laboratory of Diabetes Immunology,Ministry of Education,and Department of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University,Changsha,410011,China

出　　处：《Science China(Life Sciences)》2025年第4期1149-1157,共9页中国科学(生命科学英文版)

基　　金：supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0508200,2023ZD0508201);the National Natural Science Foundation of China(82100949,82470931);the Outstanding Young Investigator Award of Hunan Province(2022JJ10094);Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC008)to J.H;the Intramural Research Program of the U.S.National Cancer Institute(NCI),National Institutes of Health(NIH)to D.A。

摘　　要：Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D),a comprehensive assessment of this relationship is currently lacking.We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D,to evaluate potential effect modification by other factors,including genetic susceptibility,and to explore the potential mediators for such associations.The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer,cardiovascular disease,or diabetes,and had at least one validated 24-h dietary recall assessment.Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs)and 95%confidence intervals(CI)for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D.During a median follow-up of 13.6 years,4,176 incident cases of T2D were identified.In the multivariable-adjusted models,a greater intake of fiber,carbohydrates from whole grains,and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs.lowest quantile,HR[95%CI]=0.70[0.62–0.79],0.74[0.67–0.82],and 0.83[0.75–0.92],respectively,all P for trend<0.005).In contrast,a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs.lowest quantile,HR[95%CI]=1.31[1.16–1.48]and 1.19[1.09–1.31],respectively,both P for trend<0.005).Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4%to 10%lower risk of T2D(all P values<0.001).The observed associations were generally similar across population subgroups,including individuals with different genetic susceptibility to T2D.Mediation analyses of the inverse association between T2D risk and isocaloric substitution of carbohydrates from refined grains with carboh

关 键 词：dietary carbohydrate type 2 diabetes prospective cohort study UK Biobank 

分 类 号：R587.1[医药卫生—内分泌]