淡水模式生物斑马鱼剂量学模型的建立方法及应用  

Establishment and application of dosimetry model method of zebrafish in freshwater model

作　　者：贡文静 曹少飞[1] 廉冰[1] 刘立业[1] 冯青靓 李建国[1] 原寒 王欣妮 GONG Wenjing;CAO Shaofei;LIAN Bing;LIU Liye;FENG Qingliang;LI Jianguo;YUAN Han;WANG Xinni(China Institute for Radiation Protection,CNNC Key Laboratory for Radiation Protection Technology,Taiyuan 030006,China)

机构地区：[1]中国辐射防护研究院中核核环境模拟与评价技术重点实验室,太原030006

出　　处：《辐射研究与辐射工艺学报》2025年第2期98-107,共10页Journal of Radiation Research and Radiation Processing

摘　　要：通过对模式生物斑马鱼(Danio rerio,zebrafish)建立剂量学模型,得到斑马鱼对137Cs的剂量系数(DCs)及剂量率,针对核设施向环境中排放放射性核素等问题,提供有效的技术手段及数据。在实验室中采用1000 Bq/L的137Cs水溶液饲养斑马鱼,得到斑马鱼浓集因子(CR),针对模式生物斑马鱼建立整体模型和简化解剖学模型,通过蒙特卡罗模拟得到放射性核素137Cs粒子能量在斑马鱼体内的内外照射沉积能,根据公式计算得到137Cs对斑马鱼的剂量系数及剂量率。137Cs对斑马鱼整体模型内照射剂量系数计算结果为6.77×10^(−3)(μGy·h^(−1))(/Bq·kg^(−1));外照射剂量系数计算结果为3.67×10^(−2)(μGy·h^(−1))(/Bq·kg^(−1));137Cs对斑马鱼简化解剖学模型内照射剂量系数计算结果为1.24×10^(−3)(μGy·h^(−1))(/Bq·kg^(−1));外照射剂量系数计算结果为2.66×10^(−2)(μGy·h^(−1))(/Bq·kg^(−1));采用斑马鱼整体模型计算,137Cs的活度浓度达到170 Bq/L时和采用斑马鱼简化解剖学模型计算137Cs的活度浓度达到330 Bq/L时,计算斑马鱼所受的剂量率均超过ERICA筛选基准(10μGy/h)。本文基于蒙特卡罗模拟技术对模式生物斑马鱼建立了整体模型和简化解剖学模型,并将计算结果与ERICA软件工具进行比较,计算结果均在同一量级,证明本次建立的斑马鱼剂量学模型在环境辐射影响评价上应用可行。To establish a dosimetric model for zebrafish(Danio rerio)to obtain the dose coefficient and dose rate of zebrafish for 137Cs,and to provide effective technical means and data for radionuclide discharge from nuclear facilities into the environment.The zebrafish concentration factor(CR)was obtained by feeding zebrafish with a 1000 Bq/L 137Cs aqueous solution in the laboratory.Holistic and simplified anatomical models were established for zebrafish,and the internal and external irradiation deposition energies of radionuclide 137Cs particles in zebrafish were obtained by Monte Carlo simulations.The dose coefficient and dose rate of 137Cs for zebrafish were calculated according to the formula.For the holistic zebrafish model,the 137Cs dose coefficient was 6.77×10^(−3)(mGy·h^(−1))/(Bq·kg^(−1))and calculated dose coefficient of external irradiation was 3.67×10^(−2)(mGy·h^(−1))/(Bq·kg^(−1)).In the simplified anatomical model,the 137Cs dose coefficient and calculated dose coefficient of external irradiation were 1.24×10^(−3)(mGy·h^(−1))/(Bq·kg^(−1))and 2.66×10^(−2)(mGy·h^(−1))/(Bq·kg^(−1)),respectively.The activity concentrations of 137Cs reached 170 Bq/L and 330 Bq/L when using the zebrafish holistic and simplified anatomical models,respectively.The calculated dose rate of zebrafish exceeded the ERICA screening benchmark(10 mGy/h).In this study,holistic and simplified anatomical models were established for zebrafish based on Monte Carlo simulations,and the results were compared using the ERICA software tool.The calculated results were of the same order of magnitude,thereby demonstrating that the established zebrafish dosimetry model can be applied to environmental radiation impact assessments.

关 键 词：斑马鱼 整体模型 简化解剖学模型 剂量系数 剂量率 

分 类 号：TL7[核科学技术—辐射防护及环境保护] TL72