G-MDSCs在肿瘤和非肿瘤疾病中免疫调控作用的研究进展  

Research advancements of immunomodulatory role of G-MDSCs in tumor and non-tumor diseases

作　　者：刘燕 张飞[2] 祝晓雯 朱杨壮壮 邹纯朴[1] 胥孜杭 LIU Yan;ZHANG Fei;ZHU Xiaowen;ZHU-YANG Zhuangzhuang;ZOU Chunpu;XU Zihang(Shanghai Key Laboratory of Health Identification and Assessment,School of Basic Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Xin Hua Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200092,China)

机构地区：[1]上海中医药大学基础医学院上海健康辨识与评估重点实验室,上海201203 [2]上海交通大学附属新华医院,上海200092

出　　处：《中国免疫学杂志》2025年第4期990-997,共8页Chinese Journal of Immunology

基　　金：国家自然科学基金青年科学基金(81804017,81802357);国家自然科学基金面上项目(82274229);上海市自然基金面上项目(20ZR1458500);上海市科技计划项目“上海市健康辨识与评估重点实验室”(21DZ2271000);上海中医药大学杏林青年学者人才计划(A2-X200050316)。

摘　　要：粒细胞样髓源抑制细胞(G-MDSCs)是髓源抑制细胞(MDSCs)中最大的亚群,参与多种肿瘤和非肿瘤疾病的发生和发展。G-MDSCs主要通过产生Arg-1、ROS、iNOS等物质抑制免疫效应细胞(如T细胞、NK细胞)发挥免疫抑制作用。既往研究聚焦于G-MDSCs在肿瘤中的促瘤作用,但该细胞群体在非肿瘤疾病中的免疫调控作用更为复杂,且往往被忽视,尤其是在自身免疫性关节炎等疾病中发挥积极效应。此外,虽然G-MDSCs和中性粒细胞的来源和表型一致,但它们的免疫功能却大相径庭。因此,准确地区分两者可提高G-MDSCs靶向治疗的精准性,但该领域仍处于探索状态。目前国内外关于G-MDSCs的实验研究颇丰,且以肿瘤为主,但国内综述尚无全面关注G-MDSCs在肿瘤和非肿瘤疾病中免疫调控作用的报道。本文以此为切入点,总结了G-MDSCs在肿瘤和非肿瘤疾病中扮演的不同角色,以揭示G-MDSCs在免疫调控中重要且复杂的功能。Granulocytic myeloid-derived suppressor cells(G-MDSCs)are the principal subsets of myeloid-derived suppressor cells(MDSCs),which involved in development and progression of a variety of tumor and non-tumor diseases.G-MDSCs mediated disfunction of immune effector cells(such as T cells and NK cells)through producing Arg-1,ROS,iNOS,etc.is major cause of its immunosuppressive function.To date,a large number of studies have focused on tumor-promoting effects of G-MDSCs.However,their complex immunomodulatory functions,especially their positive effects in diseases such as autoimmune arthritis,are often overlooked.Besides,G-MDSCs share the same origin and phenotype with neutrophils,but their immune functions are heterogeneous.Therefore,precision of G-MDSCs targeted therapy will be largely improved if the two can be accurately distinguished,though this field is still under exploration.At present,there are abundant experimental studies on G-MDSCs at home and abroad,mainly in tumors,but there are no domestic reports on the immunomodulatory function of G-MDSCs in tumors and non-tumor diseases.Therefore,in this review,we summarizes the different roles played by G-MDSCs in tumor and non-tumor diseases,in order to reveal the important and complex functions of G-MDSCs in immune regulation.

关 键 词：G-MDSCs 肿瘤 非肿瘤疾病 免疫调控 

分 类 号：R392.12[医药卫生—免疫学]