淋巴细胞活化基因3及其在感染性疾病中作用的研究进展  

Research progress of lymphocyte activation gene 3 and its role in infectious diseases

作　　者：陈洁 徐俊驰[3] 强锐[2] 刘轩妙 陈慧 胥萍[3] CHEN Jie;XU Junchi;QIANG Rui;LIU Xuanmiao;CHEN Hui;XU Ping(Department of Clinical Laboratory,Children's Hospital of Soochow University,Suzhou 215025,China;Suzhou Medical College of Soochow University,Suzhou 215131,China;Suzhou University Affiliated Infectious Disease Hospital,Suzhou 215131,China)

机构地区：[1]苏州大学附属儿童医院检验科,苏州215025 [2]苏州大学苏州医学院,苏州215131 [3]苏州大学附属传染病医院,苏州215131

出　　处：《中国免疫学杂志》2025年第4期1016-1020,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金青年科学基金(81900577);苏州市重点学科(SZXK201814);江苏省卫生健康委科研项目面上项目(M2021066);苏州市科技计划(SZS2020311,SLJ2021017,SLT2021012,SYS2020190)。

摘　　要：感染性疾病是指病原体入侵人体引起的各种疾病。淋巴细胞活化基因3(LAG-3)是一个结构类似于CD4的负性免疫检查点分子。多数研究认为LAG-3可抑制CD4^(+)T和CD8^(+)T细胞活化和功能,在感染性疾病(获得性免疫缺陷病、活动性肺结核、慢性病毒性肝炎、恶性疟疾等)发生发展中具有调节作用,并可作为有效的潜在免疫治疗靶点。本文对LAG-3及其在感染性疾病中的作用研究进行综述。Infectious diseases refer to various diseases caused by pathogens invading human body.Lymphocyte activation gene 3(LAG-3)is a negative immune checkpoint molecule similar to CD4.Most studies have found that LAG-3 plays a regulatory role in occurrence and development of infectious diseases(acquired immunodeficiency disease,active pulmonary tuberculosis,chronic hepatitis B,falciparum malaria)via inhibiting activation and function of CD4^(+)T and CD8^(+)T cells,and can serve as an effective potential immunotherapy target.This article will summarize researches of LAG-3 and its roles in infectious disease.

关 键 词：免疫检查点 LAG-3 感染性疾病 免疫调控 

分 类 号：R392.1[医药卫生—免疫学]