细胞焦亡在类风湿关节炎中致病作用的新进展  

New progress in pathogenic effect of pyroptosis in rheumatoid arthritis

作　　者：毛婧 谭敏 郝佳瑶 张瑞 李文花 张宪萌 沈海丽[1] MAO Jing;TAN Min;HAO Jiayao;ZHANG Rui;LI Wenhua;ZHANG Xianmeng;SHEN Haili(Department of Rheumatology and Immunology,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院风湿免疫科,兰州730030

出　　处：《中国免疫学杂志》2025年第4期1021-1024,F0003,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金地区项目(81960302);甘肃省风湿免疫疾病临床医学研究中心项目(21JR7RA437);兰州大学第二医院萃英科技创新计划项目(CY2021-BJ-A01)。

摘　　要：细胞焦亡是由焦孔素(GSDMs)介导的一种新型、炎症性细胞程序性死亡方式,表现为膜孔形成和大量促炎因子释放。类风湿关节炎(RA)是一种慢性、炎症性自身免疫性疾病,以持续性多关节滑膜炎症、渐进性软骨和骨破坏为特征,最终导致关节畸形、致残。近年有研究发现细胞焦亡在RA的发生发展中具有重要作用。本文就细胞焦亡分子机制及其在RA中的致病作用、治疗策略进行综述,以期为RA的机制研究和新药开发提供新的思路和靶点。Pyroptosis is a novel,inflammatory programmed cell death mediated by gasdermins(GSDMs),which characterized by the formation of membrane pores and the release of pro-inflammatory cytokines.Rheumatoid arthritis(RA)is a chronic,inflammatory autoimmune disease characterized by persistent synovitis in multiple joints,progressive destruction of bone and cartilage,and eventually leading to joint deformity and disability.Recently,it has been shown that pyroptosis plays an important role in development of RA.This review summarizes the molecular mechanism of pyroptosis,its pathogenic role and therapeutic strategies in RA,aiming of providing new insights for the mechanism research and new drug development of RA.

关 键 词：细胞焦亡 类风湿关节炎 致病作用 

分 类 号：R392[医药卫生—免疫学]