NAT10-mediated mRNA N4-acetylcytidine modifications in mouse oocytes constitute a checkpoint of ovarian follicle development  

小鼠卵母细胞中NAT10介导的mRNA N4-乙酰胞嘧啶修饰是卵泡发育的一个检查点

作　　者：Wen-Jing Wang Yu-Ke Wu Shao-Yuan Liu Lu Chen Hong-Bo Wu Heng-Yu Fan 王文静;吴雨珂;刘绍源;陈露;吴洪波;范衡宇

机构地区：[1]Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility,Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China [2]Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [3]Department of Reproductive Medicine,Qinzhou Maternal and Child Health Care Hospital,Qinzhou 535099,China [4]Center for Biomedical Research,Shaoxing Institute,Zhejiang University,Shaoxing 312000,China

出　　处：《Science Bulletin》2025年第6期837-841,共5页科学通报(英文版)

基　　金：supported by the National Key Research and Development Program of China(2021YFC2700100);the Natural Science Foundation of Zhejiang Province(LD22C060001);the National Natural Science Foundation of China(31930031);the fellowship of China National Postdoctoral Program for Innovative Talents(BX20230031);Beijing Natural Science Foundation(7244435).

摘　　要：Proper ovarian follicle development,which is required for the maintenance of female fertility,is critical for the production of mature oocytes[1,2].Meanwhile,the correct establishment of the epitranscriptome in oocytes is essential for precise gene repression and the acquisition of developmental competence[1–5].The ac4C modification is the third most abundant chemical modification in transcriptome[6,7].NAT10,the only known writer of ac4C,has been shown to participate in physiological and disease settings[6,8–11].However,NAT10-targeted transcripts in oocytes as well as their functions in supporting folliculogenesis are poorly understood.

关 键 词：precise gene repression mature oocytes meanwhilethe ac c modification acquisition developmental competence establishment epitranscriptome physiological disease settings nat chemical modification 

分 类 号：R711.6[医药卫生—妇产科学]