NAT10 primes a post-transcriptional repertoire essential for the maintenance of spermatogonial homeostasis  

乙酰转移酶NAT10激发转录后调控维持精原细胞发育稳态

作　　者：Xiaoli Zhu Caoling Xu Xue Jiang Jiaqi Zou Wenqing Li Xuemei Xing Xiaoxiao Gao Jiao Lei Fei Meng Xin Wang Yuzhang Zhu Yu Cheng Muhammad Azhar Wenjie Han Ge Lin Yunfang Zhang Ge Shan Shen Zhang Jianqiang Bao 朱晓莉;徐曹玲;姜雪;邹佳琦;李文卿;邢雪梅;高晓晓;雷娇;孟飞;王鑫;朱昱璋;成玉;Muhammad Azhar;韩汶杰;林戈;张云芳;单革;张珅;鲍坚强

机构地区：[1]Center for Reproduction and Genetics,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China [2]Clinical Research Center for Reproduction and Genetics in Hunan Province,Reproductive and Genetic Hospital of CITIC-XIANGYA,Changsha 410000,China [3]NHC Key Laboratory of Human Stem Cell and Reproductive Engineering,School of Basic Medical Sciences,Central South University,Changsha 410075,China [4]Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China [5]School of Information Science and Technology,University of Science and Technology of China(USTC),Hefei 230001,China [6]Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Hefei National Laboratory for Physical Sciences at Microscale,Biomedical Sciences and Health Laboratory of Anhui Province,University of Science and Technology of China(USTC),Hefei 230001,China

出　　处：《Science Bulletin》2025年第6期842-846,共5页科学通报(英文版)

基　　金：supported by the National Key Research and Development Program ofChina(2019YFA0802600,2022YFC2702600);Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM"(QYPY20230032);the National Natural Science Foundation of China(31970793,32170856 and 32300711);the Anhui Provincial Natural Science Foundation grant(2408085jJ016);the Reproductive and Genetic Hospital of CITIC-XIANGYA(YNXM-202211);the Hunan Provincial Grant for Innovative Province Construction(2019SK4012);the Hundred Youth Talents Program of Hunan Province.

摘　　要：Male fertility is built on the proper proliferation and differentiation of germline cells within the seminiferous epithelium in the testis,which continuously produces millions of sperm per day in mammals[1].RNA modifications are emerging as crucial epitranscriptomic regulators.

关 键 词：proliferation differentiation germline cells post transcriptional regulation germline cells male fertility spermatogonial homeostasis epitranscriptomic regulators seminiferous epithelium 

分 类 号：R69[医药卫生—泌尿科学]