肝脏类器官在乙型肝炎病毒研究中的应用进展  

Research progress of liver organoids in hepatitis B virus

作　　者：易世豪 文娟 王欢 Yi Shihao;Wen Juan;Wang Huan(Nanshan Class of 2020,Zunyi Medical University,Zunyi Guizhou 563006,China;Key Laboratory of Infectious Disease&Biosafety,Provincial Department of Education,Zunyi Medical University,Zunyi Guizhou 563006,China)

机构地区：[1]遵义医科大学2020级南山班,贵州遵义563006 [2]遵义医科大学贵州省普通高等学校传染病与生物安全特色重点实验室,贵州遵义563006

出　　处：《遵义医科大学学报》2025年第4期408-413,共6页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81360261);贵州省教育厅资助项目[NO:黔教技(2022)027]。

摘　　要：目的乙型肝炎病毒(HBV)感染是导致肝硬化和肝癌的主要病因之一。现有的HBV研究模型存在一定的局限性,亟需一种新模型弥补其缺陷。类器官是干细胞在一定条件下分化成的由多种类型细胞组成的迷你器官,可以再现HBV感染的免疫和发病机制,用于模拟病毒在体内的感染情况。本文介绍了肝脏类器官在HBV机制研究及抗病毒药物筛选中的应用,以期为HBV的研究提供更多思路和可能。Objective Hepatitis B virus(HBV)infection is one of the major causes of liver cirrhosis and liver cancer.Existing models for HBV research have certain limitations,thus a novel model is urgently needed to compensate for their shortcomings.Organoids,which are mini-organs composed of multiple cell types differentiated from stem cells under certain conditions,can recapitulate the immunity and pathogenesis of HBV infection and be used to simulate viral infection in vivo.This paper describes the application of liver organoids in HBV mechanism research and antiviral drug screening,with the aim of providing more ideas and possibilities for HBV research.

关 键 词：乙型肝炎病毒 肝脏类器官 疾病建模 药物筛选 

分 类 号：R37[医药卫生—病原生物学]