基于NHANES分析LE8与慢性阻塞性肺疾病发病风险的关系  

Analysis of the relationship between LE8 and incidence risk of chronic obstructive pulmonary disease based on NHANES

作　　者：罗智敏 皮建彬 王文会[1] LUO Zhimin;PI Jianbin;WANG Wenhui(The Eighth Clinical School of Guangzhou University of Traditional Chinese Medicine,Foshan hospital of Traditional Chinese Medicine,Foshan 528051,Guangdong,China)

机构地区：[1]广州中医药大学第八临床医学院佛山市中医院,广东佛山528051

出　　处：《中南医学科学杂志》2025年第2期267-271,共5页Medical Science Journal of Central South China

基　　金：佛山市科技局医学科技攻关项目(2220001005469;2220001005032)。

摘　　要：目的 基于公开数据库中的大样本信息,探究LE8与COPD发病风险之间的关联。方法 提取美国国家健康和营养调查(NHANES)数据库中2013—2014年、2015—2016年、2017—2018年3个周期受试者的相关数据,使用调查加权的多变量Logistic回归分析及敏感性分析探究LE8评分与COPD发病风险之间的关系。结果 非COPD组平均LE8总评分为69.9分(69.3~70.5分),COPD组平均LE8总评分为59.5分(57.8~61.1)分。在控制了潜在的混杂因素后,较高的LE8评分与COPD发病风险降低有关(每增加10分COPD的发病率为OR=0.62;95%CI:0.58~0.67)。健康行为和健康因素评分与COPD的关联中也发现了类似的模式。在敏感性分析中,即使在倾向得分匹配以及排除有心血管病史的受试者后,LE8总评分及分量表评分(健康行为和健康因素评分)仍与COPD显著相关。结论 LE8总评分及其分量表得分(健康行为和健康因素评分)与COPD的发生率呈负相关,维持最佳的心血管健康水平可能有益于减少COPD发病风险。Aim To explore the association between LE8 and COPD risk based on extensive data from publicly accessible databases.Methods The information was extracted from three cycles(2013—2014,2015—2016,2017—2018) of the National Health and Nutrition Examination Survey(NHANES) database.Surveyed weighted multivariate logistic regression analysis and sensitivity analysis were performed to explored the associations between LE8 and COPD risk.Results The mean LE8 total score in the non-COPD group was 69.9(69.3-70.5) points,and the mean LE8 total score in the COPD group was 59.5(57.8-61.1) points.Following the control of potential confiunders,higher LE8 scores were associated with a reduced odds of COPD(odds ratio [OR] for per 10 score increase:0.62;95%CI:0.58-0.67).A similar pattern was found in the association of health behavior scores and health factor scores with COPD.In sensitivity analysis,LE8 total scores and subscale scores(health behaviors scores and health factors scores) were still significantly correlated with COPD after propensity score matching and excluding participants with cardiovascular history.Conclusion The LE8 total score and its subscales scores(health behaviors scores and health factors scores) are negatively correlated with the incidence of COPD.Maintaining optimal cardiovascular health level may be beneficial to reducing the risk of COPD.

关 键 词：LE8 慢性阻塞性肺疾病 NHANES 

分 类 号：R563.9[医药卫生—呼吸系统]