血清HDAC2、SMAD7水平与HDCP严重程度及预后关系的分析  

Analysis of the relationship between serum HDAC2 and SMAD7 levels and the severity,and prognosis of HDCP

作　　者：姜海英[1] 张桂欣[1] 宋志慧[1] 左金玲[1] 张哲 JIANG Haiying;ZHANG Guixin;SONG Zhihui;ZUO Jinling;ZHANG Zhe(Department of Gynaecology and Obstetrics,Tangshan Maternal and Child Health Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市妇幼保健院妇产科,河北唐山063000

出　　处：《中南医学科学杂志》2025年第2期288-291,共4页Medical Science Journal of Central South China

基　　金：河北省2023年度医学科学研究重点课题计划项目(20231751)。

摘　　要：目的 分析妊娠期高血压疾病(HDCP)患者血清组蛋白脱乙酰基酶2(HDAC2)、SMA和MAD相关蛋白7(SMAD7)水平及其与疾病严重程度和预后的关系。方法 选取本院就诊的213例HDCP患者作为HDCP组,依据疾病严重程度分为妊娠期高血压组105例、子痫前期组64例、重度子痫前期组44例;依据妊娠结局分为预后不良组45例和预后良好组168例;同时纳入197例健康孕妇作为对照组。采用酶联免疫吸附法检测各组血清HDAC2、SMAD7水平。采用多因素Logistic回归分析HDCP患者发生不良结局的影响因素。采用ROC曲线分析血清HDAC2、SMAD7水平对HDCP患者发生不良结局的预测效能。结果 血清HDAC2、SMAD7水平,HDCP组低于对照组(P<0.05);妊娠期高血压组>子痫前期组>重度子痫前期组(P<0.05);预后不良组低于预后良好组(P<0.05)。预后不良组重度子痫前期患者占比高于预后良好组(P<0.05)。HDAC2、SMAD7、重度子痫前期是HDCP患者发生不良结局的影响因素(P<0.05)。血清HDAC2、SMAD7联合预测HDCP患者发生不良结局的AUC值高于其单独AUC值。结论 HDAC2、SMAD7在HDCP患者血清中表达水平较低;HDAC2、SMAD7是HDCP患者发生不良结局的影响因素;其对HDCP患者发生不良结局的联合预测效能高于其单独预测效能。Aim To analyze the levels of serum recombinant histone deacetylase 2(HDAC2),SMA-and MAD-related protein 7(SMAD7) in patients with hypertensive disorder complicating pregnancy(HDCP) and their relationship with disease severity and prognosis.Methods 213 patients with HDCP who visited our hospital were selected as the HDCP group.According to the severity of the disease,they were divided into pregnancy induced hypertension group(105 cases),preeclampsia group(64 cases),and severe preeclampsia group(44 cases).According to pregnancy outcomes,there were 45 cases in the poor prognosis group and 168 cases in the good prognosis group.At the same time,197 healthy pregnant women were included as the control group.Enzyme linked immunosorbent assay was used to detect the levels of serum HDAC2 and SMAD7 in each group.Multivariate Logistic regression was applied to analyze the factors influencing adverse pregnancy outcomes in HDCP patients.The predictive efficacy of serum HDAC2 and SMAD7 levels for adverse pregnancy outcomes in HDCP patients was analyzed by using ROC curve analysis.ResultsThe levels of serum HDAC2 and SMAD7 in the HDCP group were lower than those in the control group(P<0.05),in an order of pregnancy induced hypertension group > preeclampsia group > severe preeclampsia group(P<0.05);The poor prognosis group was lower than the good prognosis group(P<0.05).The proportion of severe preeclampsia patients in the poor prognosis group was higher than that in the good prognosis group(P<0.05).HDAC2,SMAD7 and severe preeclampsia were the influencing factor for adverse pregnancy outcomes in HDCP patients(P<0.05).The AUC value of predicting adverse pregnancy outcomes in HDCP patients by combining serum HDAC2 and SMAD7 is higher than its individual AUC value.Conclusion The expression levels of HDAC2 and SMAD7 are relatively low in the serum of HDCP patients.HDAC2 and SMAD7 are the influencing factors for adverse pregnancy outcomes in patients with HDCP;The combined predictive power for adverse pregnancy outcomes in HDCP patien

关 键 词：妊娠期高血压疾病 HDAC2 SMAD7 预后 

分 类 号：R246[医药卫生—针灸推拿学]