血清URH、VASH-1、ATG7水平与2型糖尿病肾病患者病情程度及肾功能指标的相关性  

Correlation analysis of serum URH,VASH-1,and ATG7 levels with disease severity and renal function indicators in patients with type 2 diabetic nephropathy

作　　者：韦唯 汤晶 WEI Wei;TANG Jing(The Second Hospital of Huangshi,Huangshi 435000,Hubei,China;Huangshi Medical and Nursing Medical Laboratory Co.,Ltd.,Huangshi 435000,Hubei,China)

机构地区：[1]黄石市第二医院,湖北黄石435000 [2]黄石医养医学检验实验室,湖北黄石435000

出　　处：《中南医学科学杂志》2025年第2期365-368,共4页Medical Science Journal of Central South China

基　　金：湖北省科技厅科研课题(2020CFB630)。

摘　　要：目的 探讨血清尿酸/高密度脂蛋白胆固醇(URH)、内源性血管生成抑制蛋白-1(VASH-1)、自噬相关蛋白7(ATG7)水平与2型糖尿病肾病(DN)患者病情程度及肾功能指标的相关性。方法 选取150例2型DN患者,根据估算肾小球滤过率(eGFR)将患者分为轻度组(39例)、中度组(67例)、重度组(44例)。对比3组患者的URH、VASH-1、ATG7表达水平及肾功能相关指标、血糖血脂指标,并分析URH、VASH-1、ATG7与DN患者肾功能指标的相关性。结果 重度组和中度组的URH、VASH-1值高于轻度组,ATG7低于轻度组(P<0.05);重度组的URH、VASH-1值高于中度组,ATG7低于中度组(P<0.05)。重度组和中度组的ALB低于轻度组(P<0.05);重度组的ALB低于中度组(P<0.05)。重度组和中度组的BUN、Scr、UACR高于轻度组(P<0.05);重度组的BUN、Scr、UACR高于中度组(P<0.05)。DN患者的URH、VASH-1与BUN、Scr、UACR均呈正相关(P<0.05);DN患者的ATG7与BUN、Scr、UACR呈负相关(P<0.05)。DN患者的eGFR=688.91-2.09×URH-1.66×VASH-1+78.17×ATG7,URH、VASH-1、ATG7与DN患者的eGFR变化密切相关。结论 随着DN患者肾功能损伤程度加重,其血清URH、VASH-1升高,ATG7降低;且DN患者肾功能与URH、VASH-1呈正相关,与ATG7呈负相关。Aim To investigate the correlation between serum uric acid/high-density lipoprotein cholesterol(URH),vasohibin-1(VASH-1),and autophagy-related protein 7(ATG7) levels with disease severity and renal function indicators in patients with type 2 diabetic nephropathy(DN).Methods A total of 150 type 2 DN patients were selected and divided into mild(n=39),moderate(n=67),and severe(n=44) groups based on estimated glomerular filtration rate(eGFR).The levels of URH,VASH-1,ATG7,and renal function indicators,as well as blood glucose and lipid levels,were compared among the three groups.Linear correlation analysis was used to analyze the correlation between URH,VASH-1,ATG7,and renal function indicators in DN patients.Results The URH and VASH-1 levels in the severe and moderate groups were higher than those in the mild group,while ATG7 levels were lower(P<0.05).The URH and VASH-1 levels in the severe group were higher than those in the moderate group,while ATG7 levels were lower(P<0.05).The ALB levels in the severe and moderate groups were lower than those in the mild group;the ALB levels in the severe group were lower than those in the moderate group(P<0.05).The BUN,Scr,and UACR levels in the severe and moderate groups were higher than those in the mild group(P<0.05);the BUN,Scr,and UACR levels in the severe group were higher than those in the moderate group(P<0.05).URH,VASH-1 was positively correlated with BUN,Scr,whereas UACR(P<0.05);ATG7 was negatively correlated with BUN,Scr,and UACR(P<0.05).The eGFR of DN patients was calculated as 688.91-2.09×URH-1.66×VASH-1+78.17×ATG7,indicating a close relationship between URH,VASH-1,ATG7,and eGFR changes in DN patients.Conclusion As the severity of renal function impairment in DN patients increases,serum URH and VASH-1 levels rise,while ATG7 levels decrease.Renal function in DN patients is positively correlated with URH and VASH-1,while negatively correlated with ATG7.

关 键 词：2型糖尿病 肾病 尿酸 HDLC 内源性血管生成抑制蛋白-1 自噬相关蛋白7 

分 类 号：R587.2[医药卫生—内分泌]