Dual-responsive Tumbleweed-inspired Soft Robot Based on Poly(N‑isopropylacrylamide) and MoS_(2) for Targeted Drug Delivery in Stomach  

作　　者：Xiangyu Teng Shuxuan Yu Zezheng Qiao Zhixing Ge Wenguang Yang 

机构地区：[1]School of Electromechanical and Automotive Engineering,Yantai University,Yantai,264005,China [2]Department of Biomedical Engineering,National University of Singapore,Singapore,999002,Singapore

出　　处：《Journal of Bionic Engineering》2025年第2期562-573,共12页仿生工程学报(英文版)

基　　金：the financial support through National Natural Science Foundation of China(Project No.62273289);The Youth Innovation Science and Technology Support Program of Shandong Province(Project No.2022KJ274);Shandong Provincial Natural Science Foundation(ZR2024MF007);Graduate Innovation Foundation of Yantai University,GIFYTU.

摘　　要：In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N‑isopropylacrylamide) and MoS_(2). Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS_(2), the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.

关 键 词：Bioinspiration Soft robot Light-activated Magnetically actuated-Targeted drug delivery 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置]