MAP与生理盐水洗涤红细胞治疗DAT阳性自身免疫性溶血性贫血的效果对比  

The Comparison of the Efficacy of MAP and Physiological Saline Washing Red Blood Cells in the Treatment of DAT Positive Autoimmune Hemolytic Anemia

作　　者：耿晓旭 GENG Xiaoxu(Department of Blood Transfusion,Fuxin Mining General Hospital,Liaoning Health Industry Group,Fuxin 123100,Liaoning Province,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院输血科,辽宁阜新123100

出　　处：《中国实用乡村医生杂志》2025年第2期34-37,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的比较MAP与生理盐水洗涤红细胞治疗DAT阳性自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)的效果。方法选择2020年1月-2023年12月于辽宁省健康产业集团阜新矿总医院输注洗涤红细胞治疗的AIHA患者74例,将其中31例输注生理盐水洗涤红细胞者纳入对照组,将其余43例输注MAP洗涤红细胞者纳入观察组。比较两组的血液制品质量、外周血化验结果和不良反应发生率。结果两组洗涤红细胞血红蛋白含量、上清蛋白含量、溶血率差异无统计学意义(P>0.05)。观察组不同时间点洗涤红细胞血红蛋白含量、上清蛋白含量、溶血率差异无统计学意义(P>0.05)。观察组治疗后血红蛋白、红细胞计数、红细胞压积高于对照组,而总胆红素低于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为6.45%,观察组不良反应发生率为6.98%,差异无统计学意义(P>0.05)。结论MAP与生理盐水洗涤红细胞均达到国家质量要求,且MAP洗涤红细胞保存时间较长;而从治疗角度来看,MAP洗涤红细胞能够快速进一步提高AIHA患者外周血红细胞和血红蛋白水平,并且改善溶血症状;而且MAP洗涤红细胞并未增加不良反应发生率。Objective To compare the efficacy of MAP and physiological saline washing of red blood cells in the treatment of DAT positive autoimmune hemolytic anemia(AIHA).Methods A total of 74 AIHA patients who received red blood cell wash infusion therapy at Fuxin Mining General Hospital of Liaoning Health Industry Group from January 2020 to December 2023 were selected.Among them,31 patients who received red blood cell wash infusion with physiological saline were included in the control group,and the remaining 43 patients who received red blood cell wash infusion with MAP were included in the observation group.The quality of blood products,peripheral blood test results,and incidence of adverse reactions between two groups were compared.Results There was no statistically significant difference in hemoglobin content,supernatant protein content,and hemolysis rate between the two groups of washed red blood cells(P>0.05).There was no statistically significant difference in the hemoglobin content,supernatant protein content,and hemolysis rate of washed red blood cells in the observation group at different time points(P>0.05).After treatment,the hemoglobin,red blood cell count,and hematocrit of the observation group were higher than those of the control group,while the total bilirubin was lower than that of the control group(P<0.05).The incidence of adverse reactions in the control group was 6.45%,while the incidence of adverse reactions in the observation group was 6.98%(P>0.05).Conclusion Both MAP and physiological saline washing of red blood cells meet national quality requirements,and MAP washing of red blood cells has a longer storage time;from a therapeutic perspective,washing red blood cells with MAP can rapidly further increase peripheral blood red blood cell and hemoglobin levels in AIHA patients,and improve hemolysis symptoms;moreover,washing red blood cells with MAP did not increase the incidence of adverse reactions.

关 键 词：自身免疫性溶血性贫血 洗涤红细胞 输血 直接抗人球蛋白试验 

分 类 号：R556.6[医药卫生—血液循环系统疾病]