不同剂量艾司氯胺酮在剖宫产全身麻醉诱导中的应用  

Application of Different Doses of Ketamine in the Induction of General Anesthesia for Cesarean Section

作　　者：朱东岩 ZHU Dongyan(Liaoyuan Maternal and Child Hospital,Liaoyuan 136200,Jilin Province,China)

机构地区：[1]辽源市妇婴医院,吉林辽源136200

出　　处：《中国实用乡村医生杂志》2025年第2期67-70,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨不同剂量艾司氯胺酮在剖宫产全身麻醉诱导中的应用效果。方法选取2021年1月-2023年12月辽源市妇婴医院收治的120例剖宫产产妇作为研究对象,以随机数字表法分为对照组、低剂量组和高剂量组各40例。三组均进行常规静脉全麻,低剂量组、高剂量组在麻醉诱导过程中,分别给予0.25 mg/kg、0.5 mg/kg的艾司氯胺酮;对照组给予等量的生理盐水,然后进行剖宫产手术。对比三组麻醉诱导时间、麻醉恢复时间、麻醉药物剂量、术中血流动力学、术后疼痛程度评分和不良反应发生率。结果高剂量组麻醉诱导时间、麻醉药物剂量小于低剂量组和对照组,差异有统计学意义(P<0.05);而三组麻醉恢复时间差异无统计学意义(P>0.05)。三组术中各个时间点的平均动脉压、心率、血氧饱和度差异无统计学意义(P>0.05)。高剂量组术后1 h、3 h、6 h、9 h、12 h的视觉模拟评分法评分均低于低剂量组和对照组,差异有统计学意义(P<0.05)。三组不良反应发生率差异无统计学意义(P>0.05)。结论高剂量(0.5mg/kg)艾司氯胺酮在剖宫产全身麻醉诱导中,可缩短麻醉诱导时间,降低麻醉药物剂量,降低患者术后疼痛程度,而且不影响患者术中血流动力学,也不增加患者的不良反应。Objective To investigate the application effect of different doses of ketamine in induction of general anesthesia for cesarean section.Methods One hundred and twenty puerpera accepting cesarean section admitted to Liaoyuan Maternal and Child Hospital from January 2021 to December 2023 were selected as the study subjects.They were randomly divided into a control group,a low-dose group,and a high-dose group by random number table method,with 40 cases in each group.All three groups accepted intravenous general anesthesia.The low-dose and high-dose groups were given 0.25 mg/kg and 0.5 mg/kg of ketamine during anesthesia induction,while the control group was given an equal amount of physiological saline before cesarean section surgery.The anesthesia induction time,anesthesia recovery time,anesthesia drug dosage,intraoperative hemodynamics,postoperative pain score,and incidence of adverse reactions among three groups were compared.Results The induction time of anesthesia and the dosage of anesthetic drugs in the high-dose group were smaller than those in the low-dose group and smaller than those in the control group(P<0.05),and there was no difference in the recovery time of anesthesia among the three groups(P>0.05).There was no statistically significant difference in the mean arterial pressure,heart rate,and blood oxygen saturation among the three groups at various time points during surgery(P>0.05).The visual analogue scale scores of patients in the high-dose group at 1 hour,3 hours,6 hours,9 hours,and 12 hours after surgery were lower than those in the low-dose group and lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion High dose(0.5mg/kg)ketamine has a good application in the induction of general anesthesia for cesarean section.It can shorten the induction time,reduce the dosage of anesthetic drugs,reduce postoperative pain,and do not affect the hemodynamics and neonatal health of patients d

关 键 词：剖宫产 全麻诱导 艾司氯胺酮 剂量 效果 

分 类 号：R614[医药卫生—麻醉学]