Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling  

作　　者：Ailing Hao Xiangyu Dong Yannian Gou Aohua Li Jiajia Li Han Xiang Saidur Rahaman Yi Zhu Hui Zhang Wulin You Guowei Shen Changqi Luo Ou Mei Xingye Wu Lewis L.Shi Russell R.Reid Tong-Chuan He Jiaming Fan 

机构地区：[1]Ministry of Education Key Laboratory of Diagnostic Medicine,Department of Clinical Biochemistry,College of Laboratory Medicine,Chongqing Medical University,Chongqing 400016,China [2]Molecular Oncology Laboratory,Department of Orthopaedic Surgery and Rehabilitation Medicine,The University of Chicago Medical Center,Chicago,IL 60637,USA [3]Department of Orthopaedic Surgery,Beijing Hospital,National Center of Gerontology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100005,China [4]The Breast Cancer Center,Chongqing University Cancer Hospital,Chongqing 400030,China [5]Department of Orthopaedic Surgery,Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine,Wuxi,Jiangsu 214071,China [6]Department of Orthopaedic Surgery,BenQ Medical Center,The Affiliated BenQ Hospital of Nanjing Medical University,Nanjing,Jiangsu 210019,China [7]Department of Orthopaedic Surgery,Yibin Second People’s Hospital,Affiliated with West China School of Medicine,Yibin,Sichuan 644000,China [8]Department of Orthopedics,Jiangxi Hospital of Traditional Chinese Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang,Jiangxi 330006,China [9]Department of Gastrointestinal Surgery,The First Affiliated Hospital of Chongqing,Medical University,Chongqing 400016,China [10]Laboratory of Craniofacial Biology and Development,Section of Plastic and Reconstructive Surgery,Department of Surgery,The University of Chicago Medical Center,Chicago,IL 60637,USA

出　　处：《Genes & Diseases》2025年第3期64-67,共4页基因与疾病(英文)

基　　金：supported in part by research grants from the Natural Science Foundation of China(No.82102696 to J.F.);the Chongqing Natural Science Foundation of China(No.2024NSCQ-MSX0073 to J.F.);the US National Institutes of Health(No.CA226303 to T.C.H.;DE030480 to R.R.R.).

摘　　要：Hypertrophic scar and keloid are a major medical problem,which may lead to disfigurement,growth restriction,and permanent loss of function,causing severe physical,psychological,and economic burdens.1 When skin injury occurs,the wound heals through a dynamic series of physiological events,including blood clotting,granulation tissue formation,re-epithelialization,and extracellular matrix remodeling.2 However,the newly formed extracellular matrix in a scar may never achieve the flexibility or strength of the original tissue.

关 键 词：engrailed inactivation blood clottinggranulation tissue physiological eventsincluding scarless skin wound healing hypertrophic scar keloid extracellular matrix remodeling extracellular matrix skin injury 

分 类 号：R622[医药卫生—整形外科]