Research progress on the use of traditional Chinese medicine to treat diseases by regulating ferroptosis  

作　　者：Shuai Liu Xianzhen Yang Sanxia Zheng Changjing Chen Lei Qi Xiangdong Xu Denglu Zhang 

机构地区：[1]Central Laboratory,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China [2]Shandong Key Laboratory of Dominant Diseases of Traditional Chinese Medicine,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China [3]Urinary Surgery,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China [4]Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China

出　　处：《Genes & Diseases》2025年第3期347-367,共21页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.82074171,81700592).

摘　　要：Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation. It is distinguished from other forms of cell death by its unique morphological changes and characteristic fine-tuned regulatory gene network. Since its pivotalinvolvement in the pathogenesis and therapeutic interventions of various diseases, such as malignant tumors, cardiovascular and cerebrovascular diseases, and traumatic disorders, hasbeen well-established, ferroptosis has garnered significant attention in contemporary physiological and pathological research. For the advantage of alleviating the clinical symptoms andimproving life quality, traditional Chinese medicine (TCM) holds a significant position in thetreatment of these ailments. Moreover, increasing studies revealed that TCM compoundsand monomers showed evident therapeutic efficacy by regulating ferroptosis via signalingpathways that tightly regulate redox reactions, iron ion homeostasis, lipid peroxidation, and glutathione metabolism. In this paper, we summarized the current knowledge of TCM compounds and monomers in regulating ferroptosis, aiming to provide a comprehensive reviewof disease management by TCM decoction, Chinese patent medicine, and natural productsderiving from TCM through ferroptosis modulation. The formulation composition, chemicalstructure, and possible targets or mechanisms presented here offer valuable insights intothe advancement of TCM exploration.

关 键 词：Chemical construction COMPOUNDS Ferroptosis MONOMERS Traditional Chinese medicine 

分 类 号：R285[医药卫生—中药学]