布地奈德及BIP AP联合小剂量肾上腺素对老年性重症哮喘合并呼吸衰竭患者的影响  

Effect of Budesonide and BIPAP Combined with Low-Dose Epinephrine on Patients with Senile Severe Asthma Combined with Respiratory Failure

作　　者：李树云 刘爱环[2] LI Shuyun;LIU Aihuan(Department of Critical Care Medicine,Shouguang People’s Hospital,Weifang 261000,China;Department of Respiratory Medicine,Shouguang People’s Hospital,Weifang 261000,China)

机构地区：[1]山东省寿光市人民医院重症医学科,山东潍坊261000 [2]山东省寿光市人民医院呼吸内科,山东潍坊261000

出　　处：《中国伤残医学》2025年第1期53-57,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨布地奈德及双水平气道正压通气(BIPAP)联合小剂量肾上腺素对老年性重症哮喘并呼吸衰竭患者的影响。方法:回顾性分析2022年1月—2023年12月寿光市人民医院收治的76例老年性重症哮喘合并呼吸衰竭患者资料,依据治疗方式的不同将其分为对照组和研究组,各38例。对照组采用布地奈德联合BIPAP治疗,研究组则在对照组基础上联合小剂量肾上腺素治疗。两组均治疗1周。比较两组免疫功能、肺功能、血气指标及并发症发生情况。结果:治疗1周后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗1d后,且研究组高于对照组,差异均有统计学意义(P<0.05)。治疗1周后,两组第一秒用力呼气容积、用力肺活量、及第一秒用力呼气容积/用力肺活量均高于治疗1d后,且研究组均高于对照组,差异均有统计学意义(P<0.05)。治疗1周后,两组动脉血氧分压、动脉血氧饱和度水平均高于治疗前,且研究组高于对照组;动脉血二氧化碳分压水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。研究组并发症发生率为5.26%,低于对照组的21.05%,差异有统计学意义(P<0.05)。结论:布地奈德及BIPAP联合小剂量肾上腺素治疗老年性重症哮喘并呼吸衰竭患者,能更有效地提升患者的免疫功能和肺功能水平,改善血气指标,减少并发症的发生。Objective:To investigate the effects of budesonide and bi-level positive airway pressure(BIPAP)combined with low-dose Epinephrine on senile patients with severe asthma and respiratory failure.Methods:Data of 76 patients with senile severe asthma combined with respiratory failure admitted to Shouguang People’s Hospital from January 2022 to December 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,with 38 cases each.The control group was treated with Budesonide combined with BIPAP,while the study group was treated with low-dose Epinephrine.Both groups were treated for 1 week.The immune function,lung function,blood gas indexes and the occurrence of complications were compared between the two groups.Results:After after incision and thread drainage surgery one week of treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in thread drainage surgery both groups were higher than those after one day of treatment,and the study group was higher than the control group,the differences were statistically significant(P<0.05).After one week of treatment,the first second forced expiratory volume,forced vital capacity,and the first second forced expiratory volume/forced vital capacity of both groups were higher than those after one day of treatment,and the study group was higher than the control group,the differences were statistically significant(P<0.05).After one week of treatment,the partial pressure of arterial blood oxygen and saturation of arterial blood oxygen in both groups were higher than those that before treatment,and the study group was higher than the control group,and the partial pressure of arterial blood carbon dioxide was lower than that before treatment,and the study group was,which was lower than the control group,with statistical significance(P<0.05).The complication rate in the study group was 5.26%,which was lower than 21.05%in the control group,the difference was statistically significant(P<0.05).Conclusion:Budesonide and BIP

关 键 词：老年性重症哮喘 呼吸衰竭 布地奈德 双水平气道正压通气 肾上腺素 肺功能 免疫状态 

分 类 号：R56[医药卫生—呼吸系统]