全膝关节置换术后患者的血清相关细胞因子及中性粒细胞群体计数参数对早期感染的预测价值分析  

Predictive Value of Serum-Related Cytokine and Neutrophil Cell Papulation Data Parameter in Patients after Total Knee Arthroplasty in Early Infection

作　　者：单彬 赵德民 于有生 SHAN Bin;ZHAO Demin;YU Yousheng(Department of Orthopaedic Center,West Coast Second Hospital of Qingdao,Qingdao 266000,China)

机构地区：[1]山东省青岛西海岸第二医院骨科中心,山东青岛266000

出　　处：《中国伤残医学》2025年第1期71-74,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨血清白细胞介素-6(IL-6)、骨形态发生蛋白-7(BMP-7)、转化生长因子-β1(TGF-β1)、碱性成纤维细胞生长因子(bFGF)水平及中性粒细胞群体计数(NE-CPD)参数在预测全膝关节置换术(TKA)后早期感染中的价值。方法:回顾性分析2021年5月—2024年5月青岛西海岸第二医院收治的70例经TKA治疗患者的临床资料,根据患者是否发生感染分为A组(n=22)和B组(n=48),A组发生感染,B组未发生感染,分析IL-6、BMP-7、TGF-β1、NE-CPD及bFGF在TKA早期感染预测中的应用价值。结果:A组IL-6水平高于B组,BMP-7、TGF-β1、bFGF水平均低于B组,差异均有统计学意义(P<0.05)。两组NE-CPD的低中位角光散射均值(MN-LMALS-NE)相比,差异无统计学意义(P>0.05);A组NE-CPD的体积均值(MN-V-NE)、传导性均值(MN-C-NE)均高于B组,而NE-CPD的中位角光散射均值(MN-MALS-NE)、高中位角光散射均值(MN-UMALS-NE)及轴向光吸收均值(MN-AL2-NE)均低于B组,差异均有统计学意义(P<0.05)。Logistics多因素分析结果显示,IL-6、BMP-7、TGF-β1、bFGF、MV-V-NE、MN-C-NE、MN-MALS-NE、MN-UMALS-NE及MN-AL2-NE均是TKA术后早期感染的独立危险因素(P<0.05)。结论:IL-6、BMP-7、TGF-β1、NE-CPD相关指标及bFGF在TKA后早期感染的预测中均有一定的参考价值,临床可根据以上几项指标的变化,评估患者发生感染的风险,并制订相应的预防策略。Objective:To investigate the value of serum levels of interleukin-6(IL-6),bone morphogenetic protein-7(BMP-7),transforming growth factor-β1(TGF-β1),basic fibroblast growth factor(bFGF)and neutrophil Cell papulation data(NE-CPD)parameter in predicting early infection after total knee arthroplasty(TKA).Methods:The clinical data of 70 patients receiving TKA treatment in the West Coast Second Hospital of Qingdao from May 2021 to May 2024 were retrospectively analyzed.According to whether the patients had infection,they were divided into a group A(n=22)and a group B(n=48).Infection occurred in group A,while no infection occurred in group B.To analyze the application value of IL-6,BMP-7,TGF-β1,NE-CPD and bFGF in the early prediction of TKA infection.Results:The levels of IL-6 in the group A was higher than those in the group B,while the levels of BMP-7,TGF-β1 and bFGF were lower than those in the group B with statistical significance(P<0.05).There was no significant difference in the mean value of low-median angular light scattering(MN-LMALS-NE)between the two groups(P>0.05),the mean volume(MN-V-NE)and mean conductivity(MN-C-NE)of NE-CPD in the group were higher than those in the group B,the mean mean angular light scattering(MN-MALS-NE),mean angular light scattering(MN-UMALS-NE)and mean axial light absorption(MN-AL2-NE)of NE-CPD were lower than those of tue group B,with statistical significance(P<0.05).The result of Logistics multivariate analysis showed that IL-6,BMP-7,TGF-β1,bFGF,MV-V-NE,MN-C-NE,MN-MALS-NE,MN-UMALS-NE and MN-AL2-NE were independent risk factors for early infection after TKA(P<0.05).Conclusion:IL-6,BMP-7,TGF-β1,NE-CPD related indexes and bFGF all have certain reference value in predicting early infection after TKA.Clinically,the risk of infection can be assessed according to the changes of the above indexes,and corresponding prevention strategies can be formulated.

关 键 词：全膝关节置换术 感染 白细胞介素-6 骨形态发生蛋白-7 转化生长因子-Β1 中性粒细胞群体计数参数 碱性成纤维细胞生长因子 

分 类 号：R656[医药卫生—外科学]