坤宁口服液联合卡贝缩宫素治疗阴道分娩后出血产妇的效果观察  

Observation on the Effect of Kunning Oral Liquid Combined with Carbetocin in the Treatment of Puerpera with Hemorrhage after Vaginal Delivery

作　　者：张柳 曾文娟[1] ZHANG Liu;ZENG Wenjuan(Department of Obstetrics and Gynecology,Fengcheng People’s Hospital,Yichun 336000,China)

机构地区：[1]江西省丰城市人民医院妇产科,江西宜春330000

出　　处：《中国伤残医学》2025年第1期75-78,92,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:观察坤宁口服液联合卡贝缩宫素治疗阴道分娩后出血产妇的效果。方法:选取2022年7月—2024年7月丰城市人民医院收治的100例阴道分娩后出血产妇为研究对象,采用红蓝双色球法随机分组,按照1:1的比例将其分为对照组和研究组,各50例。对照组应用卡贝缩宫素治疗,研究组在对照组基础上口服坤宁口服液治疗。比较两组止血效果、不良反应发生情况、凝血及纤溶指标及血流动力学指标。结果:研究组治疗后2、12、24h的出血量均低于对照组,止血时间均短于对照组,差异均有统计学意义(P<0.05)。产后3d,研究组凝血酶原时间、活化部分凝血活酶时间均短于对照组,D-二聚体、纤维蛋白降解产物水平均低于对照组,抗凝血酶Ⅲ水平高于对照组,差异均有统计学意义(P<0.05)。产后3d,两组宫动脉收缩期峰值流速均快于治疗前,且研究组快于对照组,两组搏动指数、阻力指数均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05)。研究组的不良反应发生率为6.00%,与对照组的4.00%比较,差异无统计学意义(P>0.05)。结论:应用坤宁口服液联合卡贝缩宫素治疗阴道分娩后出血产妇止血效果较佳,显著改善凝血及纤溶指标、血流动力学指标,且安全性较高。Objective:To observe the effect of Kunning Oral Liquid combined with Carbetocin in the treatment of puerpera with hemorrhage after vaginal delivery.Methods:A total of 100 puerpera with hemorrhage after vaginal delivery admitted to Fengcheng People’s Hospital from July 2022 to July 2024 were selected as the study objects,and were randomly divided into a control group and a study group with 50 cases in each group according to the ratio of 1:1 by using red and blue two-color ball method.The control group was treated with Carbetocin,and the study group was treated with Kunning Oral Liquid on the basis of control group.The hemostatic effect,occurrence of adverse reactions,coagulation and fibrinolysis indexes and hemodynamic indexes were compared between the two groups.Results:The blood loss of the study group at 2,12 and 24 h of after treatment were lower than those of the control group,and the hemostatic time were shorter than those of the control group,with statistical significance(P<0.05).Three days after delivery,the prothrombin time and activated partial thrombin time of the study group were shorter than those of the control group,the levels of D-dimer and fibrin degradation products were lower than those of the control group,and the level of antithrombinⅢwas higher than that of the control group,with statistical significance(P<0.05).Three days after delivery,the peak systolic flow rate of uterine artery in both groups were faster than those before treatment,and the study group was faster than the control group;the pulsation index and resistance index in both groups were lower than those before treatment,and the study group were lower than those of the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the study group was 6.00%,which was not statistically significant compared with 4.00%in the control group(P>0.05).Conclusion:The application of Kunning Oral Liquid combined with Carbetocin in the treatment of puerpera with hemorrhage after vaginal delivery has a good hemos

关 键 词：出血 阴道分娩 坤宁口服液 卡贝缩宫素 

分 类 号：R71[医药卫生—妇产科学]