Skin-inspired conductive hydrogels with antibacterial and pro-angiogenic abilities customized for accelerating diabetic wound healing  

受皮肤启发具有抗菌和促血管生成能力的导电水凝胶用于加速糖尿病伤口愈合

作　　者：Xinting Yang Xiaoqian Jiang Xinbo Ning Yubin Feng Wenlai Guo Chenke Wei Maja D.Nesic Andrew K.Whittaker Wenrui Qu Bai Yang Quan Lin 杨欣婷;姜晓茜;宁信博;冯钰斌;郭文来;魏晨珂;Maja D.Nesic;Andrew K.Whittaker;瞿文瑞;杨柏;林权

机构地区：[1]State Key Laboratory of Supramolecular Structure and Materials,Colege of Chemistry,jilin University,Changchun 130012,China [2]The Second Hospital of jilin University,Changchun 130041,China [3]Based Research and Technologies COHERENCE,Department of Atomic Physics,Vinca Institute of Nuclear Sciences,National Institute of the Republic of Serbia,University of Belgrade,Belgrade 11000,Republic of Serbia [4]Australian Institute for Bioengineering and Nanotechnology,Brisbane QLD 4072,Australia

出　　处：《Science China Materials》2025年第4期1271-1284,共14页中国科学(材料科学)(英文版)

基　　金：supported by the Natural Science Foundation of Jilin Province(SKL202302002);Ministry of Science,Technological Development and Innovation of the Republic of Serbia(45103-66/2024-03/200017)。

摘　　要：Intense bacterial infection,long-term inflammatory infiltration,and inadequate vascularization make diabetic wounds non-healing.Endogenous electric fields are the basis of bioelectric signal conduction and have been shown to be the primary signal guiding cell migration and promoting tissue repair.Still,the disorder microenvironment of diabetic wounds may affect the functions of endogenous electric fields.Traditional wound dressings,such as gauzes and bandages,lead to unsatisfactory repair due to their limited infection management and inability to couple with endogenous electrical fields.In this study,we develop the PMQG hydrogel,a multifunctional hydrogel dressing with effective antibacterial properties and good electroactivity,made from acrylic acid,quaternary ammonium chitosan,and MXene nanosheets.Inspired by skin,the PMQG hydrogels have flexible mechanical properties matched to the skin,strong tissue adhesion,broad-spectrum antibacterial activity,and desirable conductivity,which could transmit electrical signals,facilitating cell migration,and thus promoting the process of wound repair.The PMQG hydrogels exhibited good antibacterial properties against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and methicillin-resistant S.aureus(MRSA),effectively controlling the infection-induced inflammation.Furthermore,incorporating MXene nanosheets into the hydrogel network enhances its reactive oxygen species scavenging ability and provides biomimetic conductivity.These anti-inflammatory properties,combined with its conductivity,help regulate the microenvironment and rebuild the endogenous electric fields,facilitating cell migration,angiogenesis,and collagen deposition,leading to a remarkable 98%wound closure by day 15 in diabetic rats,thus demonstrating superior efficacy.This novel wound dressing is expected to be an ideal therapeutic strategy for diabetic wound healing.严重的细菌感染、长期的炎症浸润和血管化不足使糖尿病创面难以愈合.内源性电场是生物电信号传导的基础,是引导细胞迁移和促进组织修复的主要信号.然而,糖尿病创面微环境的紊乱可能会影响内源性电场的功能.传统敷料,如纱布、绷带等,由于其感染管理能力有限,且不能与内源性电场耦合,导致修复效果不理想.因此,本研究以丙烯酸、季铵盐壳聚糖和MXene纳米片为原料,开发了一种具有良好抗菌性能和电活性的多功能水凝胶敷料PMQG.受皮肤启发,PMQG水凝胶具有与皮肤相匹配的柔性力学性能、强组织黏附性、广谱抗菌活性和与皮肤组织相近的电活性.可传递电信号,耦合内源性电场,促进细胞迁移,从而促进创面修复过程.PMQG水凝胶对大肠杆菌、金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌均表现出良好的抗菌性能,能够有效控制感染引起的炎症.此外,在水凝胶网络中加入MXene纳米片可增强水凝胶的活性氧清除能力并提供仿生电导率.该水凝胶有助于调节微环境和重建内源性电场,促进细胞迁移、血管生成和胶原沉积,使糖尿病大鼠创面在第15天达到98%的闭合,从而显示出卓越的疗效.这种新型伤口敷料有望成为糖尿病伤口愈合的理想治疗策略.

关 键 词：chronic diabetic wound skin-inspired conductive hydrogel endogenous electric fields wound dressing 

分 类 号：R318[医药卫生—生物医学工程]