3型固有淋巴样细胞在慢性阻塞性肺疾病中的研究进展  

Research progress of group 3 innate lymphoid cells in chronic obstructive pulmonary disease

作　　者：许毅芳 梁毅[1] Xu Yifang;Liang Yi(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院呼吸与危重症医学科,南宁530021

出　　处：《国际呼吸杂志》2025年第3期266-270,共5页International Journal of Respiration

基　　金：国家自然科学基金(82060012)。

摘　　要：3型固有淋巴样细胞(ILC3s)是固有淋巴样细胞的一个亚群,以表达维甲酸相关孤核受体γt和产生白细胞介素(IL)-17、IL-22为特征,在组织黏膜的修复、稳态、感染和炎症中发挥重要作用。ILC3s与树突状细胞、中性粒细胞密切相关,而这些细胞与IL-17、IL-22均参与了慢性阻塞性肺疾病肺组织的免疫炎症反应。本综述基于ILC3s的免疫功能,重点关注其在慢性阻塞性肺疾病中的研究进展。Group 3 innate lymphoid cells(ILC3s)are a subpopulation of innate lymphoid cells characterized by the expression of retinoic acid-related orphan receptorγt and the productions of interleukin(IL)-17 and IL-22.These cells are predominantly found in tissue mucosa and play a crucial role in repair,homeostasis,infection,and inflammation.ILC3s are closely related to dendritic cells and neutrophils,and involved in the immune inflammatory response in lung tissue associated with chronic obstructive pulmonary disease alongside IL-17 and IL-22.This review focused on the immune function of ILC3s,highlighting recent research progress in the context of chronic obstructive pulmonary disease.

关 键 词：肺疾病 慢性阻塞性 3型固有淋巴样细胞 树突状细胞 中性粒细胞 白细胞介素类 

分 类 号：R563[医药卫生—呼吸系统]