血清25(OH)D、Hcy水平对妊娠早期孕妇自然流产的预测价值  

Predictive Value of Serum 25(OH)D and Hcy Expression on Spontaneous Abortion in Early Pregnancy Women

作　　者：吴文娟 WU Wenjuan(Department of Clinical Laboratory,Women and Infants Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市妇幼保健院检验科,河南郑州450000

出　　处：《河南医学研究》2025年第8期1434-1438,共5页Henan Medical Research

摘　　要：目的 探讨血清25-羟维生素D[25(OH)D]、同型半胱氨酸(Hcy)水平对妊娠早期孕妇自然流产的预测价值。方法 回顾性收集2021年8月至2023年8月于郑州市妇幼保健院产检的180例妊娠早期孕妇的临床资料,根据是否发生自然流产分为自然流产组和正常妊娠组。统计两组孕妇一般资料及入院时血清25(OH)D、Hcy检查结果,采用logistic回归分析血清25(OH)D、Hcy水平对妊娠早期孕妇自然流产的影响,绘制受试者工作特征(ROC)曲线分析血清25(OH)D、Hcy水平对妊娠早期孕妇自然流产的预测价值。结果 180例妊娠早期孕妇中自然流产25例(13.89%),正常妊娠155例(86.11%);自然流产组血清25(OH)D、叶酸、孕酮水平低于正常妊娠组,血清Hcy水平高于正常妊娠组,差异有统计学意义(P<0.05);组间其他一般资料及实验室指标比较,差异无统计学意义(P>0.05);经logistic回归分析结果显示,血清25(OH)D水平低、叶酸水平低、孕酮水平低、Hcy水平高是妊娠早期孕妇自然流产的影响因素(P<0.05);绘制ROC曲线,结果显示,血清25(OH)D、Hcy预测妊娠早期孕妇自然流产发生的曲线下面积(AUC)分别为0.801、0.816,具有一定预测价值。结论 血清25(OH)D、Hcy水平异常表达是妊娠早期孕妇自然流产的危险因素,且其水平对妊娠早期孕妇自然流产具有一定预测价值。Objective To explore the predictive value of serum 25-hydroxyvitamin D[25(OH)D]and homocysteine(Hcy)expression for spontaneous abortion in early pregnancy.Methods A retrospective collection of clinical data was conducted on 180 early pregnancy pregnant women who underwent prenatal examinations at Women and Infants Hospital of Zhengzhou from August 2021to August 2023.They were divided into spontaneous abortion group and normal pregnancy group based on whether spontaneous abortion occurred.Statistical analysis was conducted on baseline data and serum 25(OH)D and Hcy test results of two groups of pregnant women upon admission.Logistic regression was used to investigate the impact of serum 25(OH)D and Hcy levels on spontaneous abortion in early pregnancy.Receiver operating characteristic(ROC)curves were plotted to analyze the predictive value of serum 25(OH)D and Hcy levels on spontaneous abortion in early pregnancy.Results Among 180 cases of early pregnancy,25 cases(13.89%)had natural miscarriage and 155 cases(86.11%)had normal pregnancy.The levels of serum 25(OH)D,folate,and progesterone in the spontaneous abortion group were lower than those in the normal pregnancy group,and the serum Hcy level was higher than that in the normal pregnancy group,with statistical significance(P<0.05).There was no statistically significant difference in other baseline data and laboratory indicators between groups(P>0.05).The results of logistic regression analysis showed that low serum 25(OH)D levels,low folate levels,low progesterone levels,and high Hcy levels were the influencing factors of spontaneous abortion in early pregnancy(P<0.05).ROC curve was draw,and the results show that the area under the curve(AUC)of serum 25(OH)D and Hcy for predicting spontaneous abortion in early pregnancy was 0.801 and 0.816,respectively,indicating certain predictive value.Conclusion Abnormal expression of serum 25(OH)D and Hcy levels is a risk factor for spontaneous abortion in early pregnancy,and their levels have certain predictive value for spo

关 键 词：早期妊娠 自然流产 同型半胱氨酸 25-羟维生素D 预测 

分 类 号：R714.21[医药卫生—妇产科学]