胞磷胆碱联合高频次高压氧对一氧化碳中毒患者脑血流动力学的影响  

Effect of Cytidine Combined with High-Frequency Hyperbaric Oxygen on Cerebral Hemodynamics in Patients with Carbon Monoxide Poisoning

作　　者：王付玉 WANG Fuyu(Department of Emergency,Puyang People’s Hospital,Puyang 457000,China)

机构地区：[1]濮阳市人民医院急诊科,河南濮阳457000

出　　处：《河南医学研究》2025年第8期1482-1485,共4页Henan Medical Research

摘　　要：目的 探讨胞磷胆碱联合高频次高压氧治疗一氧化碳(CO)中毒对患者脑血流动力学的影响。方法 回顾性采集2020年1月至2022年12月濮阳市人民医院收治的50例经高频次高压氧治疗的CO中毒患者的资料,纳入对照组;同期选取50例经胞磷胆碱联合高频次高压氧治疗的CO中毒患者资料,纳入观察组,两组均完成4周治疗。比较脑血流动力学指标[颈内动脉收缩期最大流速(PSV)、平均流速(MV)、阻力指数(RI)]、认知功能[采用简明精神状态检查量表(MMSE)]。统计治疗期间不良反应发生情况。结果 治疗4周,两组PSV、MV较治疗前提高,RI较治疗前降低,且与对照组比较,观察组PSV、MV高,RI低(P<0.05);治疗4周,两组MMSE评分较治疗前提高,且与对照组比较,观察组高(P<0.05)。两组治疗期间不良反应发生率差异无统计学意义(P>0.05)。结论 胞磷胆碱联合高频次高压氧治疗可改善CO中毒患者脑血流动力学,降低神经损伤标志物水平,促进患者认知功能恢复,且不增加不良反应。Objective To explore the effect of combination therapy with cytidine and high-frequency hyperbaric oxygen on cerebral hemodynamics in patients with carbon monoxide(CO)poisoning.Methods Retrospective collection of data from 50 patients with CO poisoning treated with high-frequency hyperbaric oxygen therapy at Puyang People’s Hospital from January 2020 to December 2022,and inclusion in the control group.Fifty patients with CO poisoning treated with phosphatidylcholine combined with high-frequency hyperbaric oxygen therapy were selected during the same period and included in the observation group.Both groups completed 4 weeks of treatment.The cerebral hemodynamic indicators[peak systolic velocity(PSV),mean velocity(MV),resistance index(RI)of the internal carotid artery]and cognitive function[using the mini-mental state examination(MMSE)]were compared.The occurrence of adverse reactions during the treatment period was record.Results After 4 weeks of treatment,the PSV and MV of both groups increased compared to before treatment,while the RI decreased.Compared with the control group,the observation group had higher PSV and MV,but lower RI(P<0.05).After 4 weeks of treatment,MMSE scores in both groups were higher than before treatment,and higher in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two treatment groups(P>0.05).Conclusion Cytidine combined with high-frequency hyperbaric oxygen therapy can improve cerebral hemodynamics,reduce levels of nerve injury markers,promote cognitive function recovery in patients with CO poisoning,and do not increase adverse reactions.

关 键 词：一氧化碳中毒 高压氧 胞磷胆碱 脑血流动力学 认知功能 

分 类 号：R595.1[医药卫生—内科学]