药物涂层球囊治疗冠状动脉原位大血管病变的效果  

Effect of paclitaxel-coated balloon on coronary artery macrovascular disease in situ

作　　者：李京倡[1] 胡蔓蔓[2] 周倩 刘琳[1] Li Jingchang;Hu Manman;Zhou Qian;Liu Lin(The First Ward,Department of Cardiovascular Disease,Nanyang Central Hospital,Nanyang 473000,China;Department of Blood Purification,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]河南省南阳市中心医院心血管内科一病区,473000 [2]河南省南阳市中心医院血液净化科,473000

出　　处：《临床医学》2025年第3期5-7,共3页Clinical Medicine

摘　　要：目的 观察紫杉醇药物涂层球囊(PCB)治疗冠状动脉原位大血管病变的疗效。方法 选择2020年1月至2023年4月南阳市中心医院收治的64例冠状动脉原位大血管病变患者为研究对象,按照随机数字表法分为PCB组与药物洗脱支架(DES)组,每组32例。PCB组接受PCB治疗,DES组接受DES治疗,两组均随访12个月。比较两组手术效果[最小管腔直径(MLD)、管腔狭窄程度]、远期随访结果[MLD、残余直径狭窄程度(RDS)、晚期管腔丢失(LLL)]及主要不良心血管事件(MACE)发生情况。结果 术后即刻,两组靶血管病变处MLD高于术前,管腔狭窄程度低于术前,且DES组管腔狭窄程度低于PCB组,差异有统计学意义(P<0.05)。术后12个月,两组靶血管病变处MLD、RDS、LLL、MACE发生率比较,差异未见统计学意义(P>0.05)。结论 PCB治疗冠状动脉原位大血管病变可取得与DES类似的效果,安全性也相当。Objective To observe the therapeutic effect of paclitaxel-coated balloon(PCB)oncoronary artery macrovascular disease in situ.Methods Sixty-four patients with coronary arterymacrovascular disease in situ admitted to Nanyang Central Hospital from January 2020 to April 2023were selected as the study objects.They were divided into PCB group and drug eluting stent(DES)group by random number table method,with 32 cases in each group.The PCB group received PCBtreatment,the DES group received DES treatment,and both groups were followed up for 12 months.The results of operation[minimum lumen diameter(MLD),the degree of lumen stenosis],long-termfollow-up[MLD,residual diameter stenosis(RDS),late lumen loss(LLL)]and major adversecardiovascular events(MACE)were compared between the two groups.Results Compared withbefore surgery,the MLD of target vascular lesions in both groups was increased and the degree of lumenstenosis was decreased immediately after surgery,and the degree of lumen stenosis in DES group waslower than that in PCB group(P<0.05).At 12 months after surgery,there was no significantdifference in the incidence of MLD,RDS,LLL and MACE between the two groups(P>0.05).Conclusions PCB can achieve similar effect and safety as DES in the treatment of coronary arterymacrovascular disease in situ.

关 键 词：紫杉醇药物涂层球囊 冠状动脉 原位大血管病变 药物洗脱支架 冠状动脉造影 主要不良心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]