基于络病理论探讨巨噬细胞M1/M2极化与特发性肺纤维化“肺热络瘀”间的联系  

The Relation of M1/M2 Macrophage Polarization in"Lung Heat and Collaterals Stasis"of Idiopathic Pulmonary Fibrosis(IPF)Based on the Collateral Disease Theory

作　　者：彭成飞 庞立健[2] 吕晓东[1] 王琳琳[2] 孙婉宁 刘鑫瑶 崔杨 PENG Chengfei;PANG Lijian;Lu Xiaodong;WANG Linlin;SUN Wanning;LIU Xinyao;CUI Yang(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2025年第4期16-19,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金面上项目(82274440)。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种慢性的纤维化间质性肺炎,病因尚不明确。在过去的10年中,巨噬细胞已经成为纤维化发病的重要促进因素。该文总结M1型和M2型巨噬细胞在IPF中的作用,阐述巨噬细胞M1/M2在IPF中的极化动态演变。近年来,由于络病理论备受欢迎,笔者基于其理论,深度剖析IPF“肺热络瘀”与巨噬细胞M1/M2极化动态演变之间的相关性。为特发性肺纤维化病症开拓了预防与治疗的新途径。Idiopathic pulmonary fibrosis(IPF)is a chronic fibrotic interstitial pneumonia with unknown cause.Macrophages have emerged as an important contributor to the pathogenesis of fibrosis over the past decade.This article summarizes the role of M1 and M2 macrophages in IPF and expounds the dynamic evolution of M1/M2 polarization in IPF.Based on the theory of loxopathy,the author analyses the correlation between IPF‘lung heat and collaterals stasis'and the dynamic evolution of M1/M2 macrophage polarization in IPF,so as to provide new ideas for its prevention and treatment.

关 键 词：特发性肺纤维化 络病理论 肺热络瘀 巨噬细胞 M1/M2极化 

分 类 号：R259[医药卫生—中西医结合]