基于细胞焦亡探讨慢性萎缩性胃炎脾胃湿热证的生物学机制  

Discussion on Biological Mechanism of Chronic Atrophic Gastritis with Dampness-heat of Spleen and Stomach Syndrome Based on Pyroptosis

作　　者：王秋月 郑泽宇 黄铭涵[1] 王文荣[1] WANG Qiuyue;ZHENG Zeyu;HUANG Minghan;WANG Wenrong(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350003,Fujian,China)

机构地区：[1]福建中医药大学附属第二人民医院,福建福州350003

出　　处：《实用中医内科杂志》2025年第4期30-33,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(82174365);福建省自然科学基金项目(2023J01821)。

摘　　要：慢性萎缩性胃炎(Chronic Atrophic Gastritis,CAG)属于慢性炎症性病变,为胃黏膜“炎-癌”转化的关键阶段。研究表明细胞焦亡可引发胃黏膜炎症,参与CAG的发生发展。中医脾胃湿热证与胃黏膜炎性反应有密切联系,为临床CAG的常见中医证型。湿热蕴结脾胃,损伤胃络,日久易生瘀毒,诱发癌症,脾胃湿热的病机转化与焦亡促进炎性反应,利于肿瘤形成存在共通之处。该文深入探析细胞焦亡与脾胃湿热之间的关系,从现代生物学角度探究中医脾胃湿热证CAG的分子机制,为中医运用清化湿热法治疗CAG提供相关的理论依据。Chronic atrophic gastritis(CAG)is a chronic inflammatory disease,which plays a key role in the transformation of gastric mucosa from inflammation to cancer.Studies have shown that pyroptosis can induce gastric mucosal inflammation and participate in the progression of CAG.Dampness-heat of spleen and stomach syndrome in traditional Chinese medicine(TCM)is closely associated with the inflammatory level of gastric mucosa,which is a common TCM syndrome of CAG in the clinic.Dampness and heat accumulate in spleen and stomach,damaging gastric collaterals,easily generating blood stasis and toxin over time,and inducing cancer.The pathogenesis of dampness-heat of spleen and stomach syndrome has commonalities with pyroptosis promoting inflammatory reaction and facilitating tumor development.Therefore,this paper deeply explored the relationship between pyroptosis and dampness-heat of spleen and stomach syndrome,and investigated the molecular mechanism of CAG from the perspective of modern biology,in order to provide the relevant theoretical basis for TCM using the method of clearing dampness and heat in treating CAG.

关 键 词：慢性萎缩性胃炎 脾胃湿热证 细胞焦亡 生物学机制 

分 类 号：R259[医药卫生—中西医结合]