中药通过PI3K/Akt/mTOR信号通路调控自噬延缓椎间盘退变研究进展  

Research Progress on Regulation of Autophagy by Traditional Chinese Medicine through PI3K/Akt/mTOR Signaling Pathway Affecting Intervertebral Disc Degeneration

作　　者：刘泰伯 崔海舰 戚晓楠 姚啸生 马建红[3] LIU Taibo;CUI Hajan;QI Xiaonan;YAO Xiaosheng;MA Jjanhong(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;Anshan Hospital of Traditional Chinese Medicine,Anshan 114004,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032 [3]鞍山市中医院,辽宁鞍山114004

出　　处：《实用中医内科杂志》2025年第4期71-75,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(82174398);国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023040);辽宁省自然科学基金项目(2022-YGJC-80,2022-YGJC-79)。

摘　　要：腰痛是腰椎间盘退行性疾病的常见症状,椎间盘退变(intervertebral disc degeneration,IDD)是导致腰椎间盘退行性疾病的主要原因,髓核细胞自噬是影响IDD的主要机制之一,PI3K/AKT/mTOR信号通路(mTOR通路)是调控髓核细胞自噬的经典通路。可以通过该通路调控髓核细胞自噬,延缓IDD,进而起到治疗腰椎间盘退行性疾病的作用。国内外学者开展了大量中药通过mTOR通路调控髓核细胞自噬,进而延缓IDD的研究,初步揭示了中药治疗IDD的机制。该文通过综述相关文献,为中药治疗IDD的研究提供借鉴和思路。Low back pain is a common symptom of lumbar disc degenerative disease,and intervertebral disc degeneration(IDD)is the main cause of lumbar intervertebral disc degeneration.Autophagy of nucleus pulposus cells is one of the main mechanisms affecting IDD,and the PI3K/Akt/mTOR signaling pathway(mTOR signaling pathway)is a classical pathway regulating autophagy in nucleus pulposus cells.By regulating autophagy in nucleus pulposus cells through this pathway,the progression of IDD can be slowed down,thereby treating lumbar intervertebral disc degenerative diseases.Domestic and foreign scholars have conducted extensive research on the use of traditional Chinese medicine to regulate autophagy in nucleus pulposus cells through the mTOR pathway to slow down IDD,initially revealing the mechanism of traditional Chinese medicine in treating IDD.This article reviewed relevant literature to provide reference and ideas for the study of traditional Chinese medicine in treating IDD.

关 键 词：椎间盘退变 中药 自噬 PI3K/AKT/mTOR信号通路 研究进展 

分 类 号：R681.53[医药卫生—骨科学]