基于负载槲皮素的羟基磷灰石生物材料的骨组织工程研究进展  

Research Progress of Hydroxyapatite Biomaterials Loaded with Quercetin in Bone Tissue Engineering

作　　者：于博瀚 邰东旭[2] YU Bohan;TAI Dongxu(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaonnig,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2025年第4期123-125,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：辽宁省应用基础研究计划项目(2022020320-JH2/1013)。

摘　　要：目的综述负载槲皮素的羟基磷灰石生物材料的研究进展,展望负载槲皮素材料可期研究方向和成果。方法检索PubMed、Web of Science、万方及中国知网数据库,选择各数据库建库至2023年1月收录的各类负载槲皮素的羟基磷灰石生物材料用于骨植入材料研究的相关文献,对负载槲皮素的羟基磷灰石生物材料的基本特性进行概述,对其促进骨组织修复作用进行梳理和归纳总结,讨论当前的研究热点与不足。结果负载槲皮素的羟基磷灰石生物材料具备良好的生物相容性、机械、生物特性。结论以羟基磷灰石为基体材料,借助支架结构构建技术和涂层优化工艺将有效提高生物材料的骨传导性,并且使其降解产物具备高效骨诱导性,以调控成骨、破骨细胞的基因表达,促进骨缺损后的修复重建,有望进一步实现个性化移植材料的研发。Objective To review the research progress of quercetin-loaded hydroxyapatite biomaterials,and look forward to the prospective research direction and achievements of quercetin-loaded biomaterials.Methods The databases of PubMed,Web of Science,Wanfang and China HowNet were searched,and all kinds of literatures about quercetin-loaded hydroxyapatite biomaterials used in bone implant materials collected in each database from January,2023 were selected.The basic characteristics of quercetin-loaded hydroxyapatite biomaterials were summarized,and their effects in promoting bone tissue repair were combed and summarized,and the current research hotspots and shortcomings were discussed.Results:Hydroxyapatite biomaterials loaded with quercetin have good biocompatibility,mechanical and biological characteristics.Conclusion With hydroxyapatite as the matrix material,the bone conductivity of biomaterials will be effectively improved with the help of scaffold construction technology and coating optimization technology,and its degradation products will have high bone induction,so as to regulate the gene expression of osteoblasts and osteoclasts and promote the repair and reconstruction of bone defects.It is expected to further realize the research and development of personalized transplantation materials.

关 键 词：槲皮素 骨组织工程 支架 羟基磷灰石 

分 类 号：R318.08[医药卫生—生物医学工程]