达菲林与地诺孕素在卵巢型子宫内膜异位症患者腹腔镜手术后的应用效果比较  

Comparison of the Application Effect of Dophereline and Dienogest in Patients with Ovarian Endometriosis After Laparoscopic Surgery

作　　者：张杰 ZHANG Jie(Department of Obstetrics and Gynecology,Port Hospital of Tianjin,Tianjin 300450,China)

机构地区：[1]天津港口医院妇产科,天津300450

出　　处：《医学信息》2025年第7期125-128,共4页Journal of Medical Information

摘　　要：目的研究达菲林与地诺孕素在卵巢型子宫内膜异位症(OEM)患者腹腔镜手术后的应用效果。方法经随机数字表法将天津港口医院2021年1月-2022年9月收治的OEM患者60例分为地诺孕素组30例与达菲林组30例。达菲林组采用达菲林注射治疗,地诺孕素组给予地诺孕素口服治疗,比较两组疼痛症状[慢性疼痛分级问卷法(CPG)]、卵巢储备功能[抗苗勒管激素(AMH)、卵泡刺激素(FSH)、窦状卵泡数(AFC)]、血清糖类抗原125(CA125)水平、药物副作用(围绝经期症状、阴道淋漓出血、突发性出血、骨密度下降)、复发情况。结果与治疗前比较,两组治疗后非经期下腹痛、痛经、性交痛CPG评分降低,且地诺孕素组治疗后非经期下腹痛、痛经、性交痛CPG评分低于达菲林组(P<0.05);与治疗前比较,两组治疗后AMH、FSH、AFC指标降低,但地诺孕素组治疗后AMH、FSH、AFC指标高于达菲林组(P<0.05);与治疗前比较,两组治疗后血清CA125水平降低,且地诺孕素组治疗后血清CA125水平低于达菲林组(P<0.05);地诺孕素组药物副作用发生率及治疗12个月后复发率低于达菲林组(P<0.05)。结论达菲林与地诺孕素在OEM腹腔镜手术后均具有确切效果,可缓解患者疼痛症状,改善其卵巢储备功能,下调血清CA-125水平,但后者效果更佳,复发风险更小,用药安全性相对更高。Objective To study the application effect of dipherelin and dinogest in patients with ovarian endometriosis(OEM)after laparoscopic surgery.Methods According to the random number table method,60 OEM patients admitted to the Port Hospital of Tianjin from January 2021 to September 2022 were divided into 30 patients in the dinogest group and 30 patients in the dipherelin group.The dipherelin group was treated with dipherelin injection,and the dinogest group was treated with oral dinogest.The pain symptoms[chronic pain grading questionnaire(CPG)],ovarian reserve function[anti-Müllerian hormone(AMH),follicle stimulating hormone(FSH),antral follicle count(AFC)],serum carbohydrate antigen 125(CA125)level,drug side effects(perimenopausal symptoms,vaginal bleeding,sudden bleeding,bone mineral density decreased),recurrence were compared between the two groups.Results Compared with before treatment,the CPG scores of non-menstrual lower abdominal pain,dysmenorrhea and dyspareunia in the two groups after treatment were decreased,and the CPG scores of non-menstrual lower abdominal pain,dysmenorrhea and dyspareunia in the dinogest group after treatment were lower than those in the dipherelin group(P<0.05).Compared with before treatment,the indexes of AMH,FSH and AFC in the two groups decreased after treatment,but the indexes of AMH,FSH and AFC in the dienogest group were higher than those in the dipherelin group after treatment(P<0.05).Compared with before treatment,the level of serum CA125 in the two groups decreased after treatment,and the level of serum CA125 in the dinogest group was lower than that in the diphereline group after treatment(P<0.05).The incidence of drug side effects and the recurrence rate after 12 months of treatment in the dienogest group were lower than those in the dipherelin group(P<0.05).Conclusion Diphereline and dinogest both have exact effects after OEM laparoscopic surgery,which can relieve pain symptoms,improve ovarian reserve function,and down-regulate serum CA-125 level.However,the latter has be

关 键 词：卵巢型子宫内膜异位症 达菲林 地诺孕素 腹腔镜手术 卵巢储备功能 

分 类 号：R711.71[医药卫生—妇产科学]