丹参注射液联合新活素对心衰急性发作期患者血液流变学及心功能的影响  

Effect of Danshen Injection Combined with rhBNP on Hemorheology and Cardiac Function in Patients with Acute Attack of Heart Failure

作　　者：赖伟玲 谢才有 LAI Weiling;XIE Caiyou(Internal Medicine of Integrated Medicine,Longnan Second People's Hospital,Longnan 341700,Jiangxi,China;Department of Critical Medicine,Longnan First People's Hospital,Longnan 341700,Jiangxi,China)

机构地区：[1]龙南市第二人民医院中西医结合内科,江西龙南341700 [2]龙南市第一人民医院重症医学科,江西龙南341700

出　　处：《医学信息》2025年第7期133-136,共4页Journal of Medical Information

摘　　要：目的观察丹参注射液联合新活素对心衰急性发作期患者血液流变学及心功能的影响。方法选取2021年1月-2023年9月在龙南市第二人民医院诊治的60例心衰急性发作期患者为研究对象,采用随机数字表法分为对照组和观察组,各组30例。对照组采用新活素治疗,观察组在对照组基础上给予丹参注射液治疗,比较两组临床疗效、心功能指标、血流动力学指标、不良反应发生率。结果观察组治疗总有效率高于对照组(P<0.05);观察组治疗后LVEF高于对照组,LVESV、LVEDV低于对照组(P<0.05);两组PV、FIB、HBV均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率为10.00%,与对照组的6.67%比较,差异无统计学意义(P>0.05)。结论丹参注射液联合新活素治疗心衰急性发作期效果确切,可改善血液流变学、心功能,提高治疗总有效率,且无显著不良反应,具有临床应用优势。Objective To observe the effect of Danshen injection combined with rhBNP on hemorheology and cardiac function in patients with acute attack of heart failure.Methods From January 2021 to September 2023,a total of 60 patients diagnosed with acute exacerbation of heart failure at Longnan Second People's Hospital were enrolled in this study.The patients were randomly assigned to either a control group or an observation group(30 patients each)using a random number table.The control group received recombinant human B-type natriuretic peptide(rhBNP)therapy,while the observation group was treated with Danshen injection in addition to rhBNP.Clinical efficacy,cardiac function parameters,hemodynamic indices,and the incidence of adverse reactions were compared between the two groups.Results The total treatment efficacy rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the observation group demonstrated a higher LVEF and lower LVESV and LVEDV than the control group(P<0.05).Additionally,PV,FIB,and HBV levels were significantly reduced in both groups,with the observation group showing lower values than the control group(P<0.05).The incidence of adverse reactions was 10.00%in the observation group and 6.67%in the control group,with no statistically significant difference(P>0.05).Conclusion The combination of Danshen injection and rhBNP demonstrates superior efficacy in treating acute heart failure exacerbations,improving cardiac function and hemodynamics without significantly increasing adverse reactions.

关 键 词：丹参注射液 新活素 心衰 急性发作期 血液流变学 心功能 

分 类 号：R541.6[医药卫生—心血管疾病] R259[医药卫生—内科学]