腰硬联合麻醉复合静脉全麻中罗哌卡因浓度选择对宫颈癌根治术患者疼痛阈值、氧化抗氧化系统的影响  

Effects of Ropivacaine concentration selection in combined spinal-epidural anesthesia combined with intravenous general anesthesia on pain threshold,oxidation and antioxidant system in patients with radical resection of cervical cancer

作　　者：熊勇 陈永志 XIONG Yong;CHEN Yongzhi(Department of Anesthesiology,Jingzhou Third People's Hospital,Hubei Province,Jingzhou 434000,China;Depart-ment of Anesthesiology,Jiangling Maternal and Child Health Hospital,Hubei Province,Jiangling 434100,China)

机构地区：[1]湖北省荆州市第三人民医院麻醉科,湖北荆州434000 [2]湖北省荆州市江陵县妇幼保健院麻醉科,湖北江陵434100

出　　处：《中国当代医药》2025年第9期96-99,共4页China Modern Medicine

摘　　要：目的探讨腰硬联合麻醉复合静脉全身麻醉中罗哌卡因浓度选择对宫颈癌根治术患者的影响。方法选取2020年1月至2021年10月荆州市第三人民医院90例行宫颈癌手术患者作为研究对象,按照随机数字表法分为A组和B组,每组45例。所有患者均采用腰硬联合麻醉,A组注入0.5%罗哌卡因,B组注入0.25%罗哌卡因。比较两组患者不同时间点血流动力学[平均动脉压(MAP)、心率(HR)]、疼痛阈值、氧化抗氧化系统[丙二醛(MDA)、超氧化物歧化酶(SOD)]。结果两组患者麻醉前,注药10、30 min HR、MAP水平比较,差异无统计学意义(P>0.05);A组术后1、24 h疼痛阈值高于B组,差异有统计学意义(P<0.05);两组患者麻醉前1 h、麻醉后1 h、手术结束后1 h MDA、SOD水平比较,差异无统计学意义(P>0.05)。结论不同浓度罗哌卡因腰硬联合麻醉复合静脉全身麻醉应用于宫颈癌根治术中,0.5%罗哌卡因术后早期镇痛效果更好,但二者在血流动力学、抗氧化方面均无明显差异。Objective To investigate the effect of concentration selection of Ropivacaine in combined spinal-epidural anes-thesia combined with intravenous general anesthesia on patients with radical resection of cervical cancer.Methods A total of 90 patients undergoing radical resection of cervical cancer in Jingzhou Third People's Hospital from January 2020 to October 2021 were selected as the research objects,and they were divided into group A and group B according to random number table method,with 45 cases in each group.All patients were given combined spinal-epidural anesthesia with 0.5%Ropivacaine in group A and 0.25%Ropivacaine in group B.The hemodynamics(mean arterial pressure[MAP],heart rate[HR]),pain threshold,oxidation and antioxidant system(malondialdehyde[MDA],superoxide dismutase[SOD])of the two groups were compared at different time points.Results There were no significant differences in HR and MAP levels between the two groups before anesthesia at 10 and 30 min(P>0.05).The pain thresholds of group A at 1 and 24 h after operation were higher than those of group B,and the differences were statistically significant(P<0.05).There were no significant dif-ferences in MDA and SOD levels 1 h before anesthesia,1 h after anesthesia and 1 h after operation between the two groups(P>0.05).Conclusion Different concentrations of Ropivacaine in combined spinal-epidural anesthesia combined with in-travenous general anesthesia in the application of radical resection of cervical cancer,0.5%Ropivacaine early postoperative analgesia is better,but there are no significant differences in hemodynamics,antioxidant aspects.

关 键 词：腰硬联合麻醉 罗哌卡因 宫颈癌根治术 疼痛阈值 

分 类 号：R614[医药卫生—麻醉学]