非甾体抗炎药导致的急性肾小管间质性肾炎合并膜性肾病1例报道  

A case of acute tubulointerstitial nephritis combined with membranous nephropathy caused by non-steroidal anti-inflammatory drugs

作　　者：谢婷[1] 朱冬云[1] XIE Ting;ZHU Dongyun(Department of Nephrology,Wuxi Hospital of Traditional Chinese Medicine,Wuxi,Jiangsu 214071,China)

机构地区：[1]无锡市中医医院肾病科,江苏无锡214071

出　　处：《医药前沿》2025年第12期60-63,共4页Journal of Frontiers of Medicine

摘　　要：本文报道了1例中年男性患者长期间断使用双氯芬酸钠治疗痛风后出现严重肾损害,临床表现为肾病综合征伴急性肾损伤3期,病理检查显示急性肾小管-间质损伤和肾小球节段性膜性病变。通过停止使用非甾体抗炎药(NSAIDs)并采用足量激素治疗和血液透析,患者的肾功能完全恢复,蛋白尿也在肾功能恢复后得到缓解。随访1年,患者在痛风发作时未再使用NSAIDs,肾病也未复发。This paper reports a middle-aged male patient with severe kidney damage after long-term discontinuous use of Diclofenac Sodium for gout,the clinical manifestations were nephrotic syndrome with acute kidney injury 3 stage,pathological examination showed acute renal tubulointerstitial injury and glomerular segmental membranous lesions.By discontinuing the use of non-steroidal anti-inflammatory drugs(NSAIDs)and taking adequate hormone therapy and hemodialysis,the patient's renal function is completely restored,and proteinuria is relieved after renal function is restored.After 1 year of follow-up,the patient did not use NSAIDs during the gout attack,and the kidney disease did not recur.

关 键 词：非甾体抗炎药 急性肾小管间质性肾炎 膜性肾病 急性肾损伤 肾病综合征 

分 类 号：R692[医药卫生—泌尿科学]