肌少症信号通路在老化中的角色  

Role of sarcopenia-associated signaling pathways in aging

作　　者：季小琳 徐海燕 苏建华[1,2] JI Xiao-lin;XU Hai-yan;SU Jian-hua

机构地区：[1]无锡市第二人民医院,江苏无锡214000 [2]海东市第二人民医院,青海海东810699

出　　处：《中国疗养医学》2025年第4期67-72,共6页Chinese Journal of Convalescent Medicine

基　　金：青海省科协中青年科技人才托举工程(2021QHSKXRCTJ45)。

摘　　要：随着全球人口老龄化的加剧,肌少症作为一种显著影响老年人自理能力和生活质量的疾病,已引起广泛关注。肌少症不仅与肌肉质量和力量的丧失有关,还与老年综合征密切相关,增加了衰弱、跌倒、骨折和多种慢性疾病,如代谢综合征、心血管疾病和骨质疏松症的风险。本文综述了肌少症的发病机制及其涉及的多个关键信号通路,包括AMPK、mTOR、Akt/mTOR、Myostatin/SMAD、Wnt/β-catenin和SIRT1,这些通路在肌少症的发生与发展中发挥重要作用。深入理解这些信号通路有助于开发针对肌少症的有效治疗方法。通过正确评估和监控肌少症的进展,结合信号通路的干预、生活方式调整、营养补充和社会支持,可以提升患者的独立性并减轻对医疗系统的依赖。未来的研究将继续聚焦于这些通路的调控机制,以提供个性化治疗方案,改善老年人的健康状况和生活质量。As the global population continues to age,sarcopenia becomes a widely concerned condition that significantly affects the ability to live independently and quality of life in the elderly.Sarcopenia is not only associated with the loss of muscle mass and strength,but also closely linked to geriatric syndromes,which increases the risk of frailty,falls,fractures,and various chronic diseases,such as metabolic syndrome,cardiovascular disease,and osteoporosis.This review explored the pathogenesis of sarcopenia and the key signaling pathways involved in its development and progression,including the AMPK,mTOR,Akt/mTOR,Myostatin/SMAD,Wnt/β-catenin,and SIRT1 signaling pathways.A deeper understanding of these pathways can aid in the development of effective treatments for sarcopenia.Proper assessment and monitoring of sarcopenia progression,combined with interventions targeting these pathways,lifestyle adjustments,nutritional support,and social assistance,can enhance the independence and reduce the reliance on healthcare systems of sarcopenia patients.Future research will continue to focus on the regulatory mechanisms of these pathways to offer individualized treatment,improving the health and quality of life of the elderly.

关 键 词：肌少症 老年综合征 衰老 信号传导 

分 类 号：R685[医药卫生—骨科学]