新型可扩张聚醚醚酮置换体在骨质疏松胸腰椎骨折中治疗结果的中期随访  

Mid-term follow-up and clinical experience of a novel expandable PEEK implant in osteoporotic thoraco-lumbar fractures

作　　者：陈龙[1,2] 王小阵 席金涛 鲁齐林 CHEN Long;WANG Xiaozhen;XI Jintao;LU Qilin(Department of Spine Surgery,Wuhan Integrated Traditional Chinese and Western Medicine Hospital(Affiliated Hospital of Wuhan Sports University),Hubei 430070,Wuhan,China;Medical School,University of Rostock,Mecklenburg-Vorpommern 18057,Germany;不详)

机构地区：[1]武汉中西医结合骨科医院(武汉体育学院附属医院)脊柱外科,湖北武汉430070 [2]罗斯托克大学医学院,德国梅克伦堡-前波莫瑞州罗斯托克市18057

出　　处：《实用医学杂志》2025年第8期1181-1191,共11页The Journal of Practical Medicine

基　　金：湖北省自然科学基金项目(编号:2023AFB645);武汉中西医结合骨科医院(武汉体育学院附属医院)2024年度院级科研项目(编号:WTFY202401)。

摘　　要：目的评估一种新型可扩张聚醚醚酮(polyetheretherketone,PEEK)椎体置换材料在骨质疏松胸腰椎前柱重建中的中期疗效。方法回顾性分析2020年1月至2023年12月接受椎体置换术的52例单节段骨质疏松胸腰椎骨折患者,采用胸腔镜或微创开腹术联合后路短节段骨水泥增强螺钉内固定。根据置换体材料不同分为新型PEEK组及钛网Mesh组,分别记录两组手术时间、术中失血量、术后并发症,并评估术前、术后即刻及末次随访的视觉模拟量表(visual analogue score,VAS)、Oswestry残疾指数(Oswestry disability index,ODI)、骨折节段Cobb角(local kyphotic angle,LKA)、融合节段高度D-line、椎体前缘高度(anterior vertebral body height,AVBH)、椎体后缘高度(posterior vertebral body height,PVBH)。结果所有患者顺利出院,PEEK组平均手术时间(235.28±58.69)min,术中出血量(680.00±163.30)mL。随访时长(14.12±2.44)个月。VAS评分由术前的(7.44±0.87)分降至末次随访的(2.24±0.93)分,ODI评分由术前的(42.64±4.86)分降至末次随访的(11.84±3.73)分,症状及功能均有显著改善(P<0.05)。末次随访时,LKA、D-line、AVBH较术后即刻有部分丢失(P>0.05),但较术前均有明显改善(P<0.05)。术后并发症发生率12.00%(3/25),末次随访融合率为100.00%。Mesh组同样能有效改善患者症状、功能及椎体高度(P<0.05);但是末次随访时,PEEK组的LKA、D-line、AVBH明显优于Mesh组(P<0.05)。结论基于改善疼痛及功能、维持椎体高度和畸形矫正的中期疗效,短节段骨水泥增强内固定联合新型可扩张PEEK置换体是骨质疏松胸腰椎前柱重建的一种有效选择。Objective To assess the mid-term clinical prognosis and radiological outcomes of a novel expandable PEEK(polyetheretherketone)vertebral replacement device used for anterior and middle column recon-struction in the thoracolumbar spine of osteoporotic patients.Methods A retrospective analysis was performed on 52 patients with single-segment osteoporotic thoracolumbar fractures who underwent vertebral body replacement surgery between January 2020 and December 2023.The surgical procedures included either a thoracoscopic or minimally invasive anterior approach,combined with posterior short-segment cement-augmented screw fixation.According to the type of replacement material used,patients were categorized into two groups:the novel PEEK group and the titanium Mesh cage group.Data on surgical time,intraoperative blood loss,and postoperative complications were collected.The Visual Analogue Score(VAS),Oswestry Disability Index(ODI),local kyphotic angle(LKA),fusion segment height(D-line),anterior vertebral body height(AVBH),and posterior vertebral body height(PVBH)were assessed at three stages:preoperatively,immediately postoperatively,and during the final follow-up.Results All patients were successfully discharged.In the PEEK group,the average operative time was(235.28±58.69)minutes,and intraoperative blood loss was(680.00±163.30)mL.The mean follow-up duration was(14.12±2.44)months.The VAS score decreased significantly from(7.44±0.87)preoperatively to(2.24±0.93)at the final follow-up,and the ODI score also decreased significantly from(42.64±4.86)preoperatively to(11.84±3.73)at the final follow-up,indicating substantial improvement in symptoms and function(P<0.05).At the final follow-up,LKA,D-line,and AVBH exhibited partial loss compared to immediate postoperative values(P>0.05),but they remained significantly improved compared to preoperative values(P<0.05).The postoperative complication rate was 12.00%(3/25),and the fusion rate at the final follow-up was 100.00%.Similarly,the Mesh group effectively improved patient

关 键 词：聚醚醚酮 前后入路 前柱重建 胸腰段骨折 骨质疏松 

分 类 号：R446[医药卫生—诊断学] R681.3[医药卫生—临床医学] R681.5