甘油三酯-葡萄糖指数、甘油三酯-葡萄糖-体质量指数与健康体检人群高尿酸血症发生的关系  

The comparative study of TyG and TyG-BMI index with occurrence of hyperuricemia in physical examina-tion population

作　　者：聂倩[1] 张雪梅[2] 郝志华[3] 谢若琳 刘焕欣 吴晓倩[1] 任路平[4] NIE Qian;ZHANG Xuemei;HAO Zhihua;XIE Ruolin;LIU Huanxin;WU Xiaoqian;REN Luping(Physical Examination Center of Hebei General Hospital,Shijiazhuang 050051,Hebei,China;不详)

机构地区：[1]河北省人民医院体检中心,河北石家庄050051 [2]河北省人民医院风湿免疫科,河北石家庄050051 [3]河北省人民医院保健处,河北石家庄050051 [4]河北省人民医院内分泌科,河北石家庄050051

出　　处：《实用医学杂志》2025年第8期1192-1198,共7页The Journal of Practical Medicine

基　　金：河北省医学科学研究重点研究计划基金资助项目(编号:20230287);河北省政府资助临床医学优秀人才项目(编号:ZF2025021)。

摘　　要：目的探讨甘油三酯-葡萄糖指数(TyG)和甘油三酯-葡萄糖-体质量指数(TyG-BMI)对健康体检人群高尿酸血症(HUA)发生的预测能力,筛选出合适指标作为HUA风险评价工具。方法本研究最终纳入12004名参加健康体检的研究对象,根据血清尿酸(SUA)水平分为正常组(n=9952)和HUA组(n=2052),计算TyG、Ty G-BMI,根据二者水平的四分位数将研究对象分为Q1—Q44个组。通过二元logistic回归分析比较TyG、TyG-BMI与HUA之间的相关性;采用受试者工作特征(ROC)曲线和ROC曲线下面积(AUC)评估TyG、TyG-BMI及两者联合时对HUA的预测价值并进行不同性别和年龄的亚组分析。结果HUA组TyG、TyG-BMI均较正常组明显升高。TyG-Q4、TyG-BMI-Q4组中HUA的患病率明显高于其他相应3组。二元logistic回归显示TyG、TyG-BMI水平与HUA风险正相关。TyG、TyG-BMI及两者联合预测HUA的AUC分别为0.700、0.747和0.822;男性TyG、TyG-BMI及两者联合的AUC分别为0.641、0.674、0.709,女性分别为0.742、0.776、0.829,<60岁人群TyG、TyG-BMI及两者联合的AUC分别为0.716、0.759、0.835,≥60岁人群分别为0.614、0.645、0.731。结论TyG、TyG-BMI与HUA发生风险显著相关,TyG-BMI较TyG更优,两者联合可进一步提升预测效能,尤其是在女性人群和中青年人群中。Objective To investigate the predictive capacity of the Triglyceride-Glucose(TyG)index and the Triglyceride-Glucose-Body Mass Index(TyG-BMI)for the development of hyperuricemia(HUA)in a health examination population,and to identify suitable indicators as risk assessment tools for HUA.Methods This study ultimately included 12004 participants from a health examination cohort.According to SUA levels,the partici-pants were categorized into a normal group(n=9952)and a hyperuricemia(HUA)group(n=2052).The TyG index and TyG-BMI index were calculated,and participants were further stratified into four groups(Q1—Q4)based on the quartiles of these indices.Binary logistic regression analysis was performed to assess the association between TyG,TyG-BMI,and HUA.The predictive value of TyG,TyG-BMI,and their combination for HUA was evaluated using Receiver Operating Characteristic(ROC)curves and the Area Under the Curve(AUC).Subgroup analyses were carried out by gender and age.Results The TyG and TyG-BMI indices were significantly elevated in the HUA group compared to the normal group.The prevalence of HUA was markedly higher in the TyG-Q4 and TyG-BMI-Q4 groups than in the other three corresponding quartile groups.Binary logistic regression analysis revealed a positive association between TyG,TyG-BMI levels,and the risk of HUA.The AUC values for predicting HUA using TyG,TyG-BMI,and their combination were 0.700,0.747,and 0.822,respectively.Specifically,for males,the AUC values were 0.641,0.674,and 0.709,respectively,whereas for females,they were 0.742,0.776,and 0.829,respectively.Among individuals younger than 60 years old,the AUC values were 0.716,0.759,and 0.835,respectively,while for those aged 60 years or older,the values were 0.614,0.645,and 0.731,respectively.Conclusions TyG and TyG-BMI are significantly associated with the risk of HUA.Specifically,TyG-BMI demon-strates superior predictive performance compared to TyG alone.Moreover,the combination of TyG and TyG-BMI further improves predictive accuracy,particularly among fe

关 键 词：甘油三酯葡萄糖指数 甘油三酯-葡萄糖-体质量指数 高尿酸血症 胰岛素抵抗 疾病风险 

分 类 号：R541.4[医药卫生—心血管疾病]