血管内皮细胞炎性循环生物标志物预测糖尿病重症肢体缺血的临床研究  

The study on the circulation inf lammatory biomarkers in prediction in critical limb ischemia of patients with type 2 diabetes

作　　者：牛敬荣[1] 李春民[1] NIU Jingrong;LI Chunmin(Department of Vascular Surgery,Beijing Chaoyang Hospital Affiliated to Capital Medical University,100020 Beijing,China)

机构地区：[1]首都医科大学附属北京朝阳医院血管外科,北京100020

出　　处：《免疫学杂志》2025年第1期59-64,共6页Immunological Journal

摘　　要：目的明确糖尿病患者重症肢体缺血(critical limb ischemia,CLI)的潜在预警生物标志物。方法于2020年1月至2023年12月入组明确诊断为CLI和糖尿病足溃疡(diabetic foot ulcers,DFU)需要经皮腔内血管成形及足部手术的患者共102名。检测其血清可溶性CD40配体(sCD40L)、IFN-α、IFN-γ、IL-2、IL-4、IL-6、IL-8、IL-10、IL-18等18种细胞免疫因子及炎症因子。结果sICAM-1和内皮素-1的循环血清水平与DFU愈后负相关;PAI-1和内皮素1水平则与需要重建新生血管相关;血栓调节蛋白和sCD40L的循环血清水平与新发病变及其复发相关。结论血管内皮细胞的循环血清免疫生物标志物的水平,可用于糖尿病患者CLI新发病变或复发的风险预测。Objective To identify the potential immune biomarkers of critical limb ischemia(CLI)in patients with diabetes.Methods From January 2018 to December 2023,102 patients who were definitely diagnosed as CLI and diabetes foot ulcers(DFU)requiring percutaneous transluminal angioplasty and foot surgery were enrolled.Serum levels of 18 cellular immune and inflammatory factors including soluble CD40 ligand(sCD40L),IFN-α,IFN-γ,IL-2,IL-4,IL-6,IL-8,IL-10,IL-13,IL-18,et cetera,were measured in these patients.Results The levels of circulating serum sICAM-1 and endothelin-1 showed a negative correlation with the recovery of DFU.Moreover,PAI-1 and endothelin-1 were related to the demand for neovascular reconstruction.The circulating serum levels of thrombomodulin and sCD40L were associated with new and recurrent lesions.Conclusion The level of circulating biomarkers related to the immunity of vascular endothelial cell can be used to predict the risk of new or recurrent CLI in patients with diabetes.

关 键 词：血管内皮细胞功能障碍 重症下肢缺血 糖尿病足溃疡 

分 类 号：R587.1[医药卫生—内分泌]