单核细胞与高密度脂蛋白胆固醇比值与糖尿病合并心房颤动的关系研究  

Relationship between monocyte to high-density lipoprotein cholesterol ratio and atrial fibrillation in diabetes mellitus patients

作　　者：张瑞欢 廉玉蓉 ZHANG Ruihuan;LIAN Yurong(First Clinical College,Changzhi Medical College,Changzhi,Shanxi 046013,China;Department of Cardiovascular Medicine,Linfen People's Hospital,the Seventh Clinical College of Shanxi Medical University,Linfen,Shanxi 041000,China)

机构地区：[1]长治医学院第一临床学院,山西长治046013 [2]山西医科大学第七临床医学院附属临汾市人民医院心血管内科,山西临汾041000

出　　处：《国际检验医学杂志》2025年第8期937-942,共6页International Journal of Laboratory Medicine

基　　金：山西省卫生健康委员会科研课题(2020159)。

摘　　要：目的通过分析糖尿病(DM)合并心房颤动(AF)患者的相关临床资料,探讨DM患者中单核细胞与高密度脂蛋白胆固醇比值(MHR)与AF的关系。方法选取2018年1月至2023年12月在山西医科大学第七临床医学院附属临汾市人民医院诊断为DM的132例患者为A组,139例DM合并AF患者为B组。比较两组的临床资料,应用多因素Logistic回归分析找出DM合并AF的影响因素,采用受试者工作特征(ROC)曲线评估MHR对DM合并AF的诊断价值。结果A组和B组年龄、高血压、冠心病、血小板计数、中性粒细胞、淋巴细胞、红细胞平均体积、红细胞体积分布宽度、总胆红素、结合胆红素、非结合胆红素、高密度脂蛋白胆固醇、中性粒细胞与淋巴细胞比值、MHR比较差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,MHR、年龄、高血压、冠心病是DM合并AF的独立危险因素(P<0.05)。ROC曲线分析结果显示,MHR及年龄联合MHR诊断DM合并AF的曲线下面积分别为0.578(95%CI:0.510~0.646),0.811(95%CI:0.759~0.862)。结论MHR是DM合并AF的独立危险因素,且联合年龄有着良好的诊断价值,可用于DM患者临床管理中AF发生风险的评估。Objective To explore the relationship between the monocyte to high-density lipoprotein cholesterol ratio(MHR)and atrial fibrillation(AF)in diabetes mellitus(DM)patients by analyzing the clinical data.Methods A total of 132 patients diagnosed with DM in Linfen People's Hospital,the Seventh Clinical College of Shanxi Medical University from January 2018 to December 2023 were selected as group A,and 139 patients with DM complicated with AF were selected as group B.The clinical data of the two groups were compared,and multivariate Logistic regression analysis was applied to identify the influencing factors of DM complicated with AF.The diagnostic value of MHR for AF in DM patients was evaluated by receiver operating characteristic(ROC)curve.Results There were statistically significant differences in age,hypertension,coronary heart disease,platelet count,neutrophils,lymphocytes,mean red blood cell volume,red blood cell volume distribution width,total bilirubin,conjugated bilirubin,unconjugated bilirubin,high-density lipoprotein cholesterol,neutrophil to lymphocyte ratio,and MHR between group A and group B(P<0.05).The results of multivariate Logistic analysis showed that MHR,age,hypertension,and coronary heart disease were independent risk factors for DM patients with AF(P<0.05).ROC curve analysis showed that the area under the curve of MHR and the combination of age and MHR for diagnosing DM complicated with AF were 0.578(95%CI:0.510-0.646)and 0.811(95%CI:0.759-0.862),respectively.Conclusion MHR is an independent risk factor for DM complicated with AF,and has good diagnostic value combined with age,which can be used to assess the risk of the occurrence of AF in the clinical management of DM patients.

关 键 词：心房颤动 糖尿病 单核细胞与高密度脂蛋白胆固醇比值 

分 类 号：R446.1[医药卫生—诊断学]