PAI-1、MPV/PLT与脑梗死患者梗死病灶面积及脑动脉狭窄的关系  

Relationship between PAI-1,MPV/PLT with infarct size and cerebral artery stenosis in patients with cerebral infarction

作　　者：李杰 钟子安 LI Jie;ZHONG Zian(Department of Neurology,Affiliated Hospital of Hubei University of Arts and Science/Xiangyang Central Hospital,Xiangyang,Hubei 441021,China)

机构地区：[1]湖北文理学院附属医院/襄阳市中心医院神经内科,湖北襄阳441021

出　　处：《国际检验医学杂志》2025年第8期987-991,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨纤溶酶原激活抑制物-1(PAI-1)、平均血小板体积与血小板计数比值(MPV/PLT)与脑梗死患者梗死病灶面积及脑动脉狭窄的关系。方法选取2022年1月至2024年1月该院收治的136例脑梗死患者设为观察组,另选取同期于该院行体检的136例健康者为对照组。同时,136例脑梗死患者根据梗死病灶面积分为小梗死组、中梗死组与大梗死组,根据脑动脉狭窄程度分为轻度狭窄组、中度狭窄组、重度狭窄组、闭塞组。采用酶联免疫吸附试验测定PAI-1水平,采用全自动血液分析仪检测平均血小板体积(MPV)、血小板计数(PLT),计算MPV/PLT。比较各组间PAI-1、MPV/PLT差异;采用受试者工作特征(ROC)曲线分析PAI-1、MPV/PLT对脑梗死的诊断价值;采用Spearman相关分析PAI-1、MPV/PLT与脑梗死患者梗死病灶面积及脑动脉狭窄程度的相关性。结果观察组血清PAI-1及MPV/PLT均较对照组更高(P<0.05)。ROC曲线分析结果显示,PAI-1、MPV/PLT单独诊断脑梗死的曲线下面积(AUC)分别为0.820(95%CI:0.768~0.873)、0.754(95%CI:0.695~0.814),二者联合诊断的AUC为0.896(95%CI:0.853~0.938)。大梗死组血清PAI-1及MPV/PLT均较中梗死组、小梗死组更高(P<0.05),且中梗死组上述指标水平均较小梗死组更高(P<0.05)。闭塞组血清PAI-1及MPV/PLT均较重度狭窄组、中度狭窄组、轻度狭窄组更高(P<0.05),且重度狭窄组上述指标水平均较中度狭窄组、轻度狭窄组更高(P<0.05),中度狭窄组上述指标水平均较轻度狭窄组更高(P<0.05)。Spearman相关分析显示,PAI-1、MPV/PLT与脑梗死患者梗死病灶面积和脑动脉狭窄程度均呈正相关(P<0.05)。结论脑梗死患者PAI-1、MPV/PLT异常表达,且与梗死病灶面积及脑动脉狭窄程度存在明显相关性,在疾病早期诊治及病情评估中具有重要潜在价值。Objective To investigate the relationship between plasminogen activator inhibitor-1(PAI-1)and mean platelet volume/platelet count ratio(MPV/PLT)with infarct size and cerebral artery stenosis in patients with cerebral infarction.Methods A total of 136 patients with cerebral infarction admitted the hospital from January 2022 to January 2024 were selected as observation group,and another 136 healthy individuals who underwent health check-ups were concurrently selected as control group.136 patients with cerebral infarction were divided into small infarction group,medium infarction group,and large infarction group based on the infarct size.They were also divided into mild stenosis group,moderate stenosis group,severe stenosis group,and occlusion group based on cerebral artery stenosis degree.PAI-1 level was determined using enzymelinked immunosorbent assay.Mean platelet volume and platelet count ratio were analyzed by fully automated hematology analyzer,and MPV/PLT was calculated.PAI-1 and MPV/PLT were compared among groups.Then receiver operating characteristic(ROC)curve was plotted to evaluate the value of PAI-1 and MPV/PLT in the diagnosis of cerebral infraction,and the correlation of PAI-1 and MPV/PLT with infarct size and cerebral artery stenosis degree in patients with cerebral infarction was verified using Spearman correlation analysis.Results PAI-1 and MPV/PLT were elevated in observation group compared to control group(P<0.05).ROC curve analysis yielded that the area under the curve(AUC)of single detection of PAI-1 and MPV/PLT in the diagnosis of cerebral infarction was 0.820(95%CI:0.768-0.873)and 0.754(95%CI:0.695-0.814),while the combined detection of the two reached an AUC of 0.896(95%CI:0.853-0.938).The serum PAI-1 level and MPV/PLT in the large infarction group were higher than those in the medium infarction group and small infarction group(P<0.05),and the levels of the above indicators in the medium infarction group were higher than those in the small infarction group(P<0.05).The serum PAI-1 level and M

关 键 词：纤溶酶原激活抑制物-1 平均血小板体积 血小板计数 梗死病灶面积 脑动脉狭窄 

分 类 号：R446.1[医药卫生—诊断学]